Crystal Structure and Properties of Thallium(I) Salinomycinate
Listed in
This article is not in any list yet, why not save it to one of your lists.Abstract
In this study we present the preparation and characterization of novel thallium(I) coordination compound of the polyether ionophorous antibiotic salinomycin (SalH). The complex [TlSal(H2O)] exists as two subunits SalTl1 and SalTl2 which differ slightly in their structural parameters. Sali-nomycin acts in a pentadentate coordination mode through oxygen donor atoms and the six-fold arrangement around the metal centers is completed by interaction with water molecule. In the overall complex structure, the two mononuclear species SalTl1 and SalTl2 are connected via hy-drogen bond network by third water molecule. The inclusion of the heavy metal ion into the structure of the polyether ionophore reduces its biological activity against Gram-positive microor-ganisms and cervical cancer cells at in vitro conditions.