The Role of CO₂ Lasers in Skin Rejuvenation with Dr. Face Technologies: A Review of Advanced Applications and Innovations

Background: Carbon dioxide (CO2) lasers are pivotal in dermatologic and aesthetic medicine, offering precise solutions for photoaging, rhytides, acne scars, and textural irregularities. Fractional and ultra-pulsed CO2 laser systems have enhanced safety, reduced recovery times, and expanded applications across diverse skin types. This review synthesizes advancements in CO2 laser technologies from 2015 to 2025, focusing on mechanisms, clinical efficacy, safety, and innovations, including Dr. Face Technologies’ optimized rejuvenation protocols.Methods: A systematic literature review was conducted across PubMed, Scopus, Web of Science, and Embase, adhering to PRISMA guidelines where applicable. Search terms included “CO2 laser,” “fractional CO2 laser,” “skin rejuvenation,” “photoaging,” “acne scars,” “rhytides,” “skin texture,” “clinical trials,” “systematic review,” and “meta-analysis.” Peer-reviewed studies from January 2015 to May 2025 were included, focusing on clinical outcomes and technological advancements. Data on wrinkle reduction, scar improvement, texture enhancement, pigmentation correction, and adverse events were extracted and analyzed qualitatively.Results: CO2 lasers, operating at 10,600 nm, ablate tissue via water absorption, inducing collagen remodeling and epidermal resurfacing. Fractional systems create microscopic thermal zones (MTZs), minimizing downtime. Clinical studies report 40–60% wrinkle reduction, 50–70% acne scar improvement, and 60–80% pigmentation correction, with patient satisfaction rates of 80–95%. Combination therapies, including platelet-rich plasma (PRP), radiofrequency, and Dr. Face Technologies’ protocols, enhance outcomes. Adverse effects, primarily transient erythema and edema, are manageable, with rare complications like post-inflammatory hyperpigmentation (PIH) reduced through optimized settings.Conclusions: CO2 lasers, enhanced by fractional and ultra-pulsed modalities, remain central to skin rejuvenation. Innovations in Dr. Face Technologies, combination therapies, and ethnic skin protocols promise further progress. Future research should prioritize long-term outcomes, standardized metrics, and inclusive applications to refine clinical practice.