Infection-Related Glomerulonephritis in the Setting of Mssa Bacteremia

Infection-related glomerulonephritis (IRGN) is an immune-mediated kidney disease triggered by bacterial infections, with Staphylococcus aureus increasingly recognized as a significant causative agent. This report describes a case of methicillin-sensitive Staphylococcus aureus (MSSA)-associated glomerulonephritis in a patient with a large epidural abscess. In this case report, we present a 63-year-old male with an extensive epidural abscess caused by methicillin-sensitive Staphylococcus aureus (MSSA) bacteremia. Despite surgical drainage and prolonged antibiotics, he developed acute kidney injury. Kidney biopsy revealed diffuse endocapillary proliferative glomerulonephritis with IgG and IgA immune complex deposition, consistent with infection-related glomerulonephritis. IRGN, often associated with deep-seated infections like abscesses, presents significant diagnostic challenges due to overlapping AKI etiologies. A kidney biopsy remains essential for identifying immune-mediated glomerulonephritis and guiding management. While historically linked to methicillin-resistant strains, MSSA has emerged as a significant cause of IRGN, particularly in adults and older populations. This case underscores the importance of timely infection control and a multidisciplinary approach in managing IRGN to achieve favorable outcomes.