The Association Between Atherogenic Index of Plasma and Clinical Outcomes in Peritoneal Dialysis Population

Background The atherogenic index of plasma (AIP), a prognostic indicator for cardiovascular disease, has been underexplored in relation to clinical outcomes in patients receiving peritoneal dialysis. This study aims to elucidate the relationship between baseline AIP levels and all-cause mortality, cardiovascular mortality, and peritonitis risk in this population. Methods This retrospective cohort study included incident peritoneal dialysis patients in our center from 1 January 2006 through 31 December 2021. The end of follow-up time was 31 December 2023. Participants were stratified by baseline AIP levels. Kaplan-Meier curves, Cox regression analysis, and subgroup analysis were used to evaluate associations with clinical outcomes. Results The average age of the 2,460 participants in this study was 45.9 years, and 1,456 (59.2%) of them were men. Diabetic nephropathy (19.5%) was the second most common kidney disease, after primary glomerulonephritis (60.8%). The higher AIP tertile group was statistically associated with increased risks of all-cause mortality, cardiovascular mortality, and peritonitis compared to the lowest AIP group, as evidenced by Kaplan-Meier curves and multivariate analyses. Continuous AIP levels also showed a positive correlation with all-cause mortality risk, even after controlling for covariates. Conclusion Our study highlights AIP as a predictive marker for adverse outcomes in PD patients, emphasizing its potential utility in risk stratification and clinical management.