Role of ZIP‐10 in the Regulation of innate Immunity in <em>Caenorhabditis elegans</em> During Pathogenic Infection

b-ZIP transcription factor ZIP-10 has emerged as a key regulator of innate immunity in Caenorhabditis elegans(C. elegans). ZIP-10 as a regulatory protein has multifarious role in development, stress response, metabolism, and immune modulation triggered by pathogenic infection. Since most of the immune signaling pathways are conserved across species, future studies are envisioned to provide new tools of hypothesis generation/testing aimed at deciphering fundamental defense mechanisms relevant to infectious disease(s). This review outlines recent findings regarding the unfolding novel mechanisms of positive and negative regulation of innate immunity by ZIP-10, speculated to have its role in maintaining immune homeostasis. However, the research evidence of a precise mechanism of its upstream signaling kinase and downstream effectors is limited. Furthermore, this review provides a brief insight into the complex dynamics of host-pathogen interaction where the pathogens exploit host factors to establish themselves within the system. Therefore, leveraging the high throughput screening potential of this model organism can lead to the identification of novel therapeutic strategies associated with immune dysregulation significantly relevant for translation to complex system(s).