Cell Cycle Regulation of Centrosome Duplication

Centriole duplication is a critical process for cellular organisation and function, underpinning essential activities such as cell division, microtubule organisation and ciliogenesis. This comprehensive review synthesises current knowledge on the mechanisms and regulatory pathways that control centriole duplication, highlighting key players such as PLK4, SAS-6 and STIL. We explore the intricate steps involved in the semi-conservative duplication process, from its initiation in G1-S phase to the maturation of procentrioles during the cell cycle. We also examine the consequences of dysregulated centriole duplication, which can lead to centrosome amplification and subsequent chromosomal instability, factors implicated in several cancers and developmental disorders. By integrating findings from recent studies, this review highlights the importance of centriole duplication in maintaining cellular homeostasis and its potential as a therapeutic target in disease contexts. The findings presented aim to provide a fundamental understanding that may inform future research directions and clinical interventions related to centriole biology.