Impurities in Pharmaceutical Products: Review on Qc Practices in DRCongo

Background : The World Health Organization estimates that more than 10% of the medications in use in developing nations are fake. False active ingredients or contaminants that pose a risk to public health can be found in counterfeit medications. Objective : The aim of this research was to evaluate the applicability of the quality control procedures that Kinshasa's reference laboratories employ. Methods : The analysis managers of three approved laboratories were chosen, and they were questioned regarding the kinds of analyses they performed, the tools they had, and the experience of their staff. Results : It was discovered that all of these labs could identify and measure active substances. However, only the majority active ingredient is quantified in medications containing many active compounds. Furthermore, none of the labs look into and measure contaminants, leftover solvents, or distinguish between enantiomers in final goods. These laboratories have been determined to possess the qualified personnel and up-to-date equipment necessary to perform all the tests necessary to identify and quantify contaminants ; yet, all of this potential is still underutilized. Conclusion : To guarantee the population receives the high-quality medications it is important to ensure that public health authorities aware of international quality control requirements commitment from those laboratories and are rigorously adhered to and implemented.