Glycocalyx Disintegration Is Associated with Mortality in Chronic Heart Failure

Background: Glycocalyx disintegration is associated with adverse outcome in patients with trauma or sepsis. As microvascular dysfunction has an impact on disease progression in chronic heart failure (CHF) patients, we hypothesized that changes in microcirculation might be associated with mortality. Methods: Fifty patients with ischemic and non-ischemic cardiomyopathy and conservative treatment with baseline measurements of the sublingual microcirculation (via Sidestream Darkfield videomicroscopy) were followed up for two years. Glycocalyx thickness was assessed indirectly by calculation of the perfused boundary region (PBR). Results: Loss of glycocalyx was pronounced in non-survivors after one, n=10, and two years, n=16, PBR: 2.05µm (1.88-2.15µm) vs. 1.87µm (1.66-2.03µm) and 2.04 (1.93-2.11) vs. 1.84 (1.62-1.97); p=0.042 and p= 0.003, respectively. Area under the ROC curve for the analysis of the predictive value of PBR on two- year mortality was 0.77 (p=0.003; SE: 0.07, CI (95%): 0.63-0.91). ROC curve analysis determined a PBR of 1.9µm as best predictor for two- year mortality (sensitivity: 0.81; specificity: 0.59). Moreover, multivariate regression analysis revealed PBR and functional capillary density as significant predictor of two- year mortality, p=0.036 and p=0.048, respectively. Conclusion: Glycocalyx disintegration is related to poor overall survival in CHF patients.