A Review of KSHV/HHV8-Associated Neoplasms and Related Lymphoproliferative Lesions

There has been extensive research in the field of KSHV/HHV8 virus, which has led to the development in the understanding of KSHV/HHV8 transmission, viral pathogenesis, how the virus drives neoplastic lesions, and how we can combat these processes. On extensive review of literature, only two true KSHV/HHV8 positive lymphoid neoplasms are described: Primary effusion lymphoma (PEL), which can also present as solid or extra-cavitary primary effusion lymphoma (EC-PEL) and diffuse large B-cell lymphoma (DLBCL). Two lymphoproliferative disorders have also been described, and while they are not true monotypic neoplasms, these lesions can transform into neoplasms: KSHV/HHV8 positive germinotropic lymphoproliferative disorder (GLPD) and Multicentric Castleman's disease (MCD). This review provides a somewhat concise overview of information related to KSHV/HHV8 positive lymphoid neoplasms and pertinent associated lymphoproliferative lesions.