Increased Pre-Operative Lung Immune Prognostic Index Score Is a Prognostic Factor in Cases of Pathological T3 Renal Cell Carcinoma

We examined the efficacy of the lung immune prognostic index (LIPI) for predicting the progression of pathological T3 renal cell carcinoma (RCC). The LIPI scores of patients with pathological T3 RCC were calculated in the pre-operative and post-operative phases. Patients were divided into the zero-points, one-point, and two-points groups according to their LIPI score and into the upstage and non-upstage groups according to the pre- and post-operative increase in LIPI score. Overall survival (OS) was evaluated using Kaplan–Meier curves stratified by group. Univariate and multivariate analyses of OS was performed via Cox proportional hazard regression analysis. LIPI scores were calculated in 80 patients for whom blood sampling data were available. The upstage and non-upstage groups comprised 8 and 72 patients, respectively. Kaplan–Meier curves showed a significant difference in the pre- to post-operative LIPI score upstage group. LIPI score change was a poor prognostic factor in univariate analysis (OS: hazard ratio [HR] = 4.10, 95% confidence interval [CI] = 1.07–15.61, P = 0.038) and multivariate analysis (OS: HR = 4.38, 95% CI = 1.13–16.89, P = 0.031). An increase in LIPI score in the pre-operative phase is a poor prognostic factor in pathological T3 RCC.