CRISPR-Cas Systems in Human Disease: A Targeted Review of Innovations Across Five Disorders

Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)-Cas technology has revolutionized molecular biology and therapeutic research. In this review, we highlight a focused analysis of CRISPR-Cas applications in the treatment and study of five major human diseases based on select peer-reviewed articles. While not exhaustive, our investigation provides insight into trends, mutation targets, and experimental outcomes, highlighting the evolving landscape of CRISPR as a therapeutic tool. We also discuss challenges, emerging tools like Cas12, Cas13, and Cas15, and future directions.