Multi-Omics Elucidation of Yoga's Systemic Protective Effects: ceRNA-Controlled Immune-Metabolic Hubs Bridge Lifestyle Intervention to Disease Prevention<span style="mso-fareast-font-family: DengXian; mso-fareast-theme-font: minor-fareast; mso-fareast-language: ZH-CN;">
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Yoga demonstrates systemic physiological benefits, but its molecular mechanisms remain unclear. This multi-omics study explores transcriptomic and immune dynamics following yoga intervention. Analyzing the GSE44777 dataset, we identified 1,260 differentially expressed genes enriched in lipid metabolism, atherosclerosis, and cancer pathways. Protein-protein interaction networks revealed HBEGF, SQLE, and BCL6 as immune-metabolic hubs. A nomogram incorporating HBEGF/SQLE predicted neuropathic pain with high accuracy (AUC = 0.831). Yoga significantly reduced neutrophil infiltration (p < 0.001) and enhanced monocyte-CD4+ T cell coordination. HBEGF emerged as a dual-functional hub linking antibacterial immunity to inflammasome activation. Competitive endogenous RNA (ceRNA) network analysis uncovered HBEGF regulation by hsa-miR-29a-3p and lncRNAs, suggesting post-transcriptional control. These findings elucidate yoga’s role in reprogramming immune-metabolic networks through transcriptional and ceRNA-mediated mechanisms, supporting its application in precision prevention of cardiovascular diseases, cancer, and neuropathic pain.