Silver Nanoparticles Synthesis Used Polyvinylpyrrolidone and Their Functionalization with Clindamycin

The synthesis of silver nanoparticles (AgNPs), must be a controlled process in order to obtain nanoparticles of adequate morphology and size according to the purpose pursued. The aim of this study was to perform a synthesis of AgNPs and the complex formed with antibiotics clindamycin, that could be functionalized with dental materials to improve their drug-bond fungicidal and bactericidal. The synthesis of nanoparticles was achieved by forming a conjugate from a chemical reduction of silver nitrate (AgNO₃) with polyvinylpyrrolidone (PVP) as a reducing agent and used in medicine because it is an inert and environmentally friendly polymer, polyethylene glycol (PEG) was also used as a stabilizing agent, resulting in the formation of AgNPs with a diameter of less than 100 nm. The plasmon resonance of AgNPs was detected at a wavelength of 426 nm, and the AgNPs-clindamycin complex was detected at 443 nm. This was done in order to functionalize them with acrylic polymers for dental use, with the goal of generating a bactericidal and fungicidal effect with drugs such as clindamycin. The results obtained suggest that it may be possible to use nanospheres linked to clindamycin, based on its antimicrobial properties and characteristics in biomedicine.