Optimization of a T-Cell Resonator: Towards Highly Sensitive Photoacoustic Spectroscopy for Non-Invasive Blood Glucose Detection

Noninvasive blood glucose monitoring is crucial for diabetes management, and photoacoustic spectroscopy (PAS) offers a promising solution by detecting glucose levels through the human skin. However, weak acoustic signals in PAS systems require optimized resonator designs for enhanced detection sensitivity. Designing such resonators physically is complex, requiring precise identification of critical parameters before practical implementation. This study focuses on optimizing a T-shaped photoacoustic resonator using finite element modeling in a COMSOL Multiphysics environment. By systematically varying the geometric design parameters of the T-cell resonator, a maximum increase in pressure amplitude of 12.76 times with a quality factor (Q-factor) of 47.5 was achieved to the previously designed reference acoustic resonator. This study takes a significant step forward by identifying key geometric parameters that influence resonator performance, paving the way for more sensitive and reliable noninvasive glucose monitoring systems.