Genomic DNA Needs an Electronic Circuit

DNA functions are regulated by a theoretical electronic circuit that could promote a prompt gene response, conformational transitions, chromosome structuring, and assist the winding of the strands around histones to meet cellular needs. While mitochondria are recognized as the battery apparatus for cell function and nucleus activities, attributing semiconductive abilities to the sole DNA strands has proven inconsistent. In contrast, Nuclear Aggregates of Polyamines (NAPs), supramolecular compounds formed by the interaction of polyamines (putrescine, sper-midine, and spermine) with phosphate ions, are credible candidates when complexed on for electron conduction. The final effect of their assembly is the formation of nanotubes that envelop the DNA and assist the strands in their functions. Furthermore, NAPs show the typical structure of an organic semiconductor, having an aromatic-like arrangement of their monomeric rings and a pseudo-phosphorene nanoribbon disposition of the phosphates located at their apical re-gion. We point at these compounds as the missing elements for a more complete understanding of the cell nucleus physiology and as perspective models for the production of organic electronic nanodevices. NAPs nanotubes wrap around the DNA double strands, creating the structural characteristics of an electronic circuit essential for genomic functions.