Gain of Body Fat and Intake of Energy in Rats with Low Dose of Caloric and Non-Caloric Sweeteners Used in Reformulation Beverage in Mexico

In Mexico and worldwide, the increase in the prevalence of overweight and obesity are associated with the consumption of sugary drinks. Therefore, in 2014, Mexico imple-mented a tax of one peso per liter on sugary drinks, in response, industry reformulated these beverages, but their health effects are little known. Rats’ males and females were in-cluded, who consumed beverages with caloric (CS) and non-caloric sweeteners (NCS) for 16 weeks. The weight, food and beverage intake of the animal was recorded weekly. At the end of the treatment, the gonadal (GAT), mesenteric (MAT) and retroperitoneal (RAT) ad-ipose tissue was dissecting; serum metabolic indicators were quantified. No differences were observed in weight gain, but there were higher beverage and energy intake, mainly in female rats. All groups with CS and NCS increased 2.0-2.4 or 1.3-1.9 times their intake of beverages, respectively, compared to control groups. With dextrose intake, males’ rats showed a higher amount of GAT and MAT, and RAT in Stevia group. The males’ rats of CS and NCS groups presented higher concentration of triglycerides. The consumption of CS and NCS of the beverages reformulated in México has effects on the volume ingested as well as metabolic and adiposity indicators, therefore they should not be considered in-nocuous.