The Presumptive Role of Oxidative Stress in Long-COVID and Its Potential Treatment with the Glutathione

An increasing consequence of the COVID-19 pandemic is the growing population of individuals with long-covid (LC). Due to its chronic nature, the prevalence of LC greatly exceeds that of acute COVID-19 illness. Additionally, it can affect persons after mild or even asymptomatic SARS-Cov-2 infection. Its persistence and multiple debilitating symptoms negatively impacts the lives and livelihood of tens of millions of individuals and causes an economic burden of $ trillions. Its pathophysiology is not well established, and no accepted treatment is currently available. This review presents evidence of the possible role of oxidative stress (OS) in LC and the potential use of glutathione to address OS and thereby treat LC.