Factors, Associated with Mortality in Patients with Chronic Heart Failure

Chronic heart failure (CHF) is one of the leading causes of mortality. Many factors may influence the risk of mortality in patients with CHF. Therefore, predictors of mortality in patients with CHF should be clarified. Aim of the study was to determine predictors of unfavorable prognosis in patients with CHF. Methods. 591 patients (median age 71.0 (64.0-80.0) years, 339 (57.4%) men) with CHF were enrolled into the “Samara Region Registry of CHF” during 1-month period in 2022 at 60 centers. The follow-up period was 18 months. During follow-up period 198 (33.5%) patients died. Results. Prognostic factors associated with mortality in patients with CHF according to the results of multivariate analysis were age (OR 1.034, 95% confidence interval (CI) 1.018-1.051, p<0.001), LVEF < 40% (OR 1.381, 95% CI 1.014-1.880, p=0.040), NYHA IV class (OR 1.932, 95% CI 1.354-2.757), p<0.001), oxygen therapy at outpatients (OR 2.668, 95% CI 1.482-4.802, p=0.001), in-hospital inotropic therapy (OR 1.463, 95% CI 0.972-2.201, p=0.068), ascites (OR 1.543, 95% CI 0.982-2.425, p=0.06), gender (male) (OR 1.354, 95% CI 0.971-1.887, p=0.074). Previous cardiovascular surgery had an inverse relationship with the probability of death (OR 0.481, 95% CI 0.322-0.718, p<0.001). Conclusions. Predictors of mortality in patients with CHF during 18-months follow-up were age, LVEF<40%, NYHA IV class of CHF, oxygen therapy in outpatient, in-hospital inotropic therapy, ascites and male gender. Previous cardiovascular surgery had favourable effect on mortality in these patients.