Impact of Radix Astragali and Panax natoginseng on Short-Term Outcomes in Acute Kidney Injury: A Retrospective Study

Background: Acute kidney injury (AKI) is a global health concern with limited treatment options. Radix Astragali and Panax notoginseng, widely used in Chinese herbal medicine, have shown nephroprotective potential. This study evaluated their impact on AKI recovery.Methods: A retrospective study was conducted at our Hospital(2012–2022). Univariate and multifactor logistic regression analyses assessed the effects of Radix Astragali and Panax notoginseng on short-term AKI outcomes.Results: Radix Astragali (RR=0.33, P=0.01, 95%CI:[0.13, 0.53]) and its combination with Panax notoginseng (RR=0.31, P=0.01, 95%CI:[0.11, 0.50]) significantly improved AKI recovery. Other positive factors included albumin levels (RR=0.02, P=0.03), ICU admission (RR=0.43, P=0.01), hemoglobin levels (RR=0.01, P=0.01), and diabetes mellitus (RR=0.22, P=0.04).Conclusion: Radix Astragali and Panax notoginseng enhance AKI recovery, particularly at peak serum creatinine levels, suggesting their potential as therapeutic options for AKI management.