The Binding and Effects of Boron-Containing Compounds on G-Protein Coupled Receptors

Boron-containing compounds (BCC) have emerged as potential drugs. The effects of letting act as drugs are mainly by means of action on enzymes. Moreover, no crystal structure shows binding to G-Protein coupled receptors (GPCRs), albeit if those are recognized as targets in many diseases. However, some experimental data support the effects of specific BCC on GPCRs. Objective: Updating data about the reported effects that suggest or support interactions of BCC on GPCR. Methods: Data were collected and reviewed from the National Center of Biotechnology Information, PubMed, Global Health, Embase, the Web of Science, and Google Scholar databases. Results: Some experimental reports support the interactions of BCC in several GPCRs, acting as labels, agonists, or antagonists on them. Details of interaction can be inferred by in silico and in vitro results. Albeit if not a crystal structure showing such a complex. Conclusions: The action of BCCs on GPCR is beyond a presumptive proposal. Evidence supports the interaction and actions of BCCs on GPCRs.