FERMENZA Postbiotic Gel: A Comprehensive Dual Action Solution for Acne Vulgaris and Malassezia Folliculitis

Acne vulgaris and Malassezia folliculitis are common dermatological conditions that require effective treatments to avoid antimicrobial resistance development. Natural postbiotic extracts, offers a potential alternative therapy due to its antimicrobial, anti-inflammatory, and skin-renewing properties. This study aims to evaluate the antimicrobial efficacy, chemical composition, and efficacy assessment of FERMENZA postbiotic gel for the treatment of acne vulgaris and malassezia folliculitis, in comparison to traditional antimicrobial treatments. Metabolite profiling of the postbiotic extract through LC-MS analysis revealed presence of compounds such as gallic acid and ellagic acid, which exhibit synergistic antimicrobial and anti-inflammatory properties. The postbiotic extract and FERMENZA gel showed significant antimicrobial activity, with inhibition rates of 85% and 81%, respectively, against P. acnes (MTCC 1951) compared to clindamycin 2% active ingredient. The MIC50 for FERMENZA postbiotic gel against P. acnes was 0.25 mg/ml. The MIC potency against M. furfur (MTCC 1374) was found to be 8 mg/ml in our previous study which was comparable to ketoconazole 2% active ingredient. Time-kill assays confirmed that FERMENZA gel reduced bacterial counts within 24 hours, with efficacy comparable to clindamycin 2% marketed gel. Nucleotide efflux assays indicated that postbiotic components compromised bacterial membrane integrity, causing leakage of intracellular contents. Stability studies showed that FERMENZA gel remained stable and within acceptable limits for all tested parameters over six months. Consumer trials indicated that FERMENZA gel provided superior pain relief and fading of acne spots compared to clindamycin, with a gentle, non-irritating formulation. This study positions FERMENZA postbiotic gel as a promising alternative for the treatment of Acne vulgaris and Malassezia folliculitis. The formulation's dual-action mechanism, driven by natural phenolic acids and polyphenols, provides an effective, sustainable solution without the risks of resistance development.