The Role of Genetic Factors and Its Relationship with Immunity in Asthma Associated with IBD Based on Integrated Bioinformatics Analysis

Read the full article See related articles

Listed in

This article is not in any list yet, why not save it to one of your lists.
Log in to save this article

Abstract

The occurrence of asthma combined with IBD has been found in clinical practice, but the pathogenesis is not fully understood,this study is to use the bioinformatics technology to explore the related genes of asthma associated with IBD and its potential biological function. Transcriptomes dataset for asthma and IBD were screened by GEO data base. Cases in the datasets are divided into the case group and the control group. Differentially expressed genes with P<0.05 and | log2FC |>2 were selected. The intersected genes were used for GO and KEGG analysis. Cibersortx was used to analyze the relationship between differentially expressed genes and immune cells.ANXA3, TNFRSF21 and ZDHHC19 were significant in both pathogenesis of asthma and IBD. It was found that TNFRSF21 was positively correlated with plasma cells in asthma, negatively correlated with neutrophil function, and negatively correlated with NK cell activation in IBD. In conclusion, ANXA3, TNFRSF21, and ZDHHC19 were selected as the intersected genes associated with asthma and IBD, which may contribute to the development of the disease via cell membrane function and S-palmitoylation. The low expression of TNFRSF21 may lead to the disorder of immune function and the morbidity of patients with asthma associated with IBD.

Article activity feed