Liposomal Drug Delivery Systems: An Intro as a Primer for Advanced Therapeutics

Application of liposomal drug delivery systems-a revolutionary approach applied in the modern therapeutic era-has shown great efficiency in elevating the level of efficacy and safety delivery drugs. Lipid-based vesicles enclose therapeutic agents with enhanced solubility, stability, and controlled release. Since their composition comprises both hydrophilic and hydrophobic drug components, it is possible for liposomes to encapsulate the latter as a way of overcoming some of the main challenges that come with the use of classical delivery systems. Some of the most significant clinical applications of liposomal formulations have been Doxil® for anticancer treatment and AmBisome® in fungal infections that significantly improved their pharmacokinetics and reduced toxicity. Liposomes have also served as very efficient carriers in delivering vaccines, where they were extremely useful in an mRNA vaccine formulation to elicit intense immune responses. The scope of liposomal systems for personalized medicine and targeted therapies is vast and keeps opening up the avenues of novel treatments to treat complex medical challenges. This paper is a review of the mechanism, advantages, clinical applications, and future prospects of liposomal drug delivery systems in modern therapeutics. Further highlighted with the development of new liposomal formulations and its inclusion with new technologies, it underlines the importance of liposomes in future drug delivery.