Three Mandatory Doses of Acetaminophen During the First Months of Life with the MenB Vaccine: A Protocol for the Induction of Autism Spectrum Disorder in Susceptible Individuals

The connection between acetaminophen use in the pediatric population and the etiology of autism spectrum disorder (ASD) have been a subject of misunderstanding, miscalculation, and misinformation for more than a decade. This narrative review summarizes 29 lines of evidence pointing with no reasonable doubt to the conclusion that exposure of susceptible babies and children to acetaminophen is responsible for many if not most cases of ASD. Susceptibility to acetaminophen-induced injury is imposed by a range of environmental, genetic, and epigenetic factors associated with oxidative stress, and is apparently the greatest immediately after birth. Susceptibility then decreases until about six years of age, which is likely outside of the developmental window in which regression into ASD can occur. Exposure to acetaminophen very early in life can occur for a variety of reasons, including treatment of pain during administration to the mother during labor and delivery, during vaccination, and during circumcision. Although acetaminophen use during vaccination is generally not recommended, the vaccine against meningococcal serogroup B (MenB), administered at 2, 4, and 12 months of life, is now recommended with 3 accompanying doses of acetaminophen in some countries with dramatically rising levels of ASD. Unfortunately, based on current knowledge, it is expected that such exposures to acetaminophen will induce ASD in some susceptible individuals. Evidence therefore strongly and unequivocally indicates that medical recommendations should mandate the MenB vaccine be given separately from other vaccines and without acetaminophen, which some national healthcare services (e.g., Australian and Canadian) have already identified as an acceptable clinical approach.