The Applications of s-Triazine Based Compounds as Potential Antifungal Agents: A Mini-Review
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Invasive fungal infections (IFIs) pose a serious threat to human health and are associated with high morbidity and mortality. In addition, the emergence of drug-resistant fungi has created an unmet medical need for the development of new classes of antifungal agents. The s-triazines are six-membered, nitrogen-containing heterocyclic scaffolds with a broad range of biological properties and have received considerable attention in medical chemistry. This review highlights recent literature reports of s-triazines derivatives as potential antifungal agents with a focus on their structure-activity relationships (SAR) which paves the way for the design and synthesis of more active s-triazine antifungal candidates.