Analysis of the Antioxidant Activity and Antimicrobial, Cytotoxic and Anti-Migratory Properties of the Essential Oils Obtained from Cultivated Medicinal Lamiaceae Species

This study aims to highlight the therapeutic potential of some Lamiacea essential oils (EO’s). For this purpose, there was evaluated in-vitro the antioxidant, cytotoxic antimicrobial and anti-migratory activity of 8 essential oils of Lavandula angustifolia Mill. (LA1), Lavandula angustifolia Mill. (LA2), Salvia officinalis L. (SO), Lavandula hybrida Balb. ex Ging (LH), Salvia sclarea L. (SS), Mentha smithiana L. (MS), Perovskia atriplicifolia Benth. (PA) and Mentha x piperita L. (MP). The longest time for total reduction of DPPH by the antioxidants in the sample was required in the case of Perovskia atripicifolia (PA). For the determination of antimicrobial activity, the reference strains used for testing were: Salmonella enterica serotype typhimurium, Shigella flexneri serotype 2b, Enterococcus faecalis, Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa, Staphylococcus aureus, Candida albicans and Candida parapsilosis. The most intense inhibitory effect was observed in EO’s of MS and MxP, on all tested microbial strains. The cytotoxic and anti-migratory activity of EO’s was tested on two melanoma cell lines (A375 and B164A5) and on a healthy keratinocyte line (HaCaT). EO’s LA1 and MxP manifested the highest selectivity on the analysed tumoral cells, by reducing their migration in comparison with the control, proofing to have therapeutic potential.