<span class="word">A <span class="word"><span class="changedDisabled">Novel <span class="word"><span class="changedDisabled">Technique <span class="word">for <span class="word"><span class="changedDisabled">Hernia <span class="word"><span class="changedDisabled">Repair <span class="word"><span class="changedDisabled">Using <span class="word">a <span class="word allCaps">UV-<span class="word"><span class="changedDisabled">Sensitive, <span class="word"><span class="changedDisabled">Adhesive <span class="word"><span class="changedDisabled">Biomaterial <span class="word">for <span class="word"><span class="changedDisabled">Hybrid <span class="word"><span class="changedDisabled">Mesh <span class="word"><span class="changedDisabled">Fixation

Background: Mesh implantation is the standard of care in hernia repair. However, penetrating suture fixation may contribute to chronic pain and tissue irritation. This pilot study evaluates the feasibility of a hybrid fixation technique using a biodegradable UV-curable adhesive biomaterial in inguinal hernia repair.Methods: Ten male patients (20-40 years) with unilateral inguinal hernia underwent open repair and were allocated into two groups (n = 5 each): hybrid fixation approach (part of the mesh was secured conventionally and the remaining portion was stabilized with an experimental adhesive UV-curable biomaterial within 3 minutes) and conventional mesh fixation. Pain (VAS) and patient-reported outcomes (CCS, EuraHS QoL, SF-36) were assessed at day 1, day 8, 6 weeks, 12 months, and 24 months. Ultrasonography and thermography were analysed when available as exploratory assessments.Results: The adhesive-assisted partial self-stabilization reduced operative time compared with conventional fixation (52.0 ± 3.1 vs 60.2 ± 3.7 min). Postoperative pain (VAS) in the hybrid group decreased from 2.6 ± 0.55 on day 1 to 0.8 ± 0.84 on day 8, with complete resolution by 6 weeks. Foreign-body sensation (CCS) decreased from day 1 to 6 weeks in both groups (hybrid: 54.08% to 30.38%, control: 65.32% to 36.57%). No intraoperative complications and no hernia recurrences were observed during the 24-month follow-up. Overall SF-36 scores increased from 77.8 preoperatively to 92.4 at 24 months. Conclusions: In this pilot cohort, hybrid fixation using the UV-curable adhesive was feasible and was associated with shorter operative time, with no intraoperative complications and no recurrences observed during follow-up. Further studies of hybrid mesh fixation on larger cohorts are warranted.