The Dynamic Regenerative Scaffold of the Stenting & Shielding Hernia System for Abdominal Hernioplasty Promotes Neo-Nervegenesis in Experimental Porcine Model

Background Prosthetic repair of abdominal wall hernias often leads to complications due to fixation and poor tissue integration. To overcome these issues, the Stenting & Shielding (S&S) Hernia System, a fixation-free 3D scaffold made of TPE, was developed. Tested in a porcine model, the device's dynamic compliance during abdominal movements promoted enhanced tissue regeneration, including the formation of new muscle fibers, blood vessels, and notably, neo-neurogenesis. Methods This study aimed to quantify and characterize the neural ingrowth within the 3D scaffold of the S&S device over various period: short, medium, long, and extra-long term following implantation in experimental pigs. Biopsy specimens were excised from the 3D scaffold of the S&S device to assess the extent and quality of neo-nervegenesis. Results The Findings revealed newly formed nervous structures within biopsy specimens. In the short term, multiple nerve fiber clusters were identified. By the midterm, these nerves showed increased maturation, ultimately culminating in fully developed neural components in the long term stage. Conclusion The observed development of highly specialized nervous elements within The S&S device marks a significant advancement in enhancing biological response in abdominal hernioplasty. By fostering the regrowth of essential tissue components within the abdominal wall, the S&S device may effectively reverse the degenerative processes underlying hernia formation, promoting true tissue regeneration and potentially improving postoperative outcomes for patients.