Assessing the Role of Vaccination in the Control of Hand, Foot, and Mouth Disease Transmission

Vaccination's impact on the dynamics of HFMD transmission is explored in this paper, considering a fractional-order derivative system of equations. This model provides vaccination strategies and characterizes local and global stability using Lyapunov functions. This work computes the basic reproduction number ($R_0$) to characterize the endemic and epidemic scenarios. Besides, sensitivity analysis was performed to identify the most critical parameters responsible for the disease dissemination. The fractional-order model captures the memory effect in infectious disease dynamics, providing further insight into modeling HFMD transmission compared to a traditional integer-order model. The results would contribute to effective vaccination strategies and public health interventions against HFMD.