Post-acute Sequelae of SARS-CoV2: A Narrative Review and Meta-Analysis of Individual Symptom Frequencies

  1. Rachel Atchley-Challenner
  2. Zachary H. Strasser
  3. Deepti Pant
  4. Aparna Krisnamoorthy
  5. Lori B. Chibnik
  6. Elizabeth W. Karlson
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Abstract

Objective: To summarize the prevalence of PASC/Long COVID symptoms among the general population reported in published articles. This narrative review examined 21 PASC symptoms. Methods: A PubMed/manual search returned 114 articles on general PASC/Long COVID symptoms. Manuscripts were excluded if they were not research studies, didn’t report symptom prevalence, or used a pediatric population. Ninety-eight studies were selected for review and 59 met criteria for inclusion. Risk of bias was assessed with the Hoy critical appraisal tool. Results: After excluding studies with high risk of bias, meta-analysis of prevalence for 21 symptom categories ranged from 2.6-28.7% in studies based on surveys to 0.3%-7.1% in studies based on EHR data. Conclusions: PASC symptom studies are limited by variability in study design and representation of the general population. Further research is needed to effectively cluster symptoms in meaningful ways that enable focused treatment.

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  1. Version published to 10.20944/preprints202403.1309.v1