The age pattern of the male-to-female ratio in mortality from COVID-19 mirrors that of cardiovascular disease in the general population
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SciScore for 10.1101/2020.07.10.20149013: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
Institutional Review Board Statement not detected. Randomization not detected. Blinding not detected. Power Analysis not detected. Sex as a biological variable not detected. Table 2: Resources
Software and Algorithms Sentences Resources Plots and data visualizations were created using the ggplot2 package in R (https://ggplot2.tidyverse.org). ggplot2suggested: (ggplot2, RRID:SCR_014601)Results from OddPub: We did not detect open data. We also did not detect open code. Researchers are encouraged to share open data when possible (see Nature blog).
Results from LimitationRecognizer: We detected the following sentences addressing limitations in the study:Limitations: Limitations to this study include: (a) potential …
SciScore for 10.1101/2020.07.10.20149013: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
Institutional Review Board Statement not detected. Randomization not detected. Blinding not detected. Power Analysis not detected. Sex as a biological variable not detected. Table 2: Resources
Software and Algorithms Sentences Resources Plots and data visualizations were created using the ggplot2 package in R (https://ggplot2.tidyverse.org). ggplot2suggested: (ggplot2, RRID:SCR_014601)Results from OddPub: We did not detect open data. We also did not detect open code. Researchers are encouraged to share open data when possible (see Nature blog).
Results from LimitationRecognizer: We detected the following sentences addressing limitations in the study:Limitations: Limitations to this study include: (a) potential differences in reporting COVID-19 deaths between the countries analyzed; (b) the lack of linked individual-level health and social databases; and (c) no information on the sex ratio of survival rates among people who acquired COVID-19. The latter would require, at a minimum, COVID-19 infection rates by age and sex in the general population (including asymptomatic infections) in order to determine whether there are sex- and age-based differences in survival from it. Additionally, the study does not account for some anomalies in the overall similar patterns for COVID-19 and CVD in the United States versus Europe. The peak sex ratio for COVID-19 occurs at an earlier age in the United States than Europe, and the sex ratio for CVD mortality is higher for Europe than the United States until the older age groups. Finally, we could not rule out that finding the lowest sex ratios in COVID-19 and CVD for the oldest age groups was partly due to selection by survival in that males who survive to an exceptionally old age are “escapers” who hardly represent the general population of older males, whereas females who survive to such an old age might be “delayers” who largely represent the general population of older females30. Conclusions: Our analyses show similar trends in the sex ratio by age of mortality from COVID-19 and from CVD. We propose that these findings might be due to some shared underlying biological mechanisms. Ind...
Results from TrialIdentifier: We found the following clinical trial numbers in your paper:
Identifier Status Title NCT04359329 Recruiting Estrogen Patch for COVID-19 Symptoms NCT04365127 Completed Progesterone for the Treatment of COVID-19 in Hospitalized M… Results from Barzooka: We did not find any issues relating to the usage of bar graphs.
Results from JetFighter: We did not find any issues relating to colormaps.
Results from rtransparent:- Thank you for including a conflict of interest statement. Authors are encouraged to include this statement when submitting to a journal.
- Thank you for including a funding statement. Authors are encouraged to include this statement when submitting to a journal.
- No protocol registration statement was detected.
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