ACE2 and TMPRSS2 variants and expression as candidates to sex and country differences in COVID-19 severity in Italy
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SciScore for 10.1101/2020.03.30.20047878: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
Institutional Review Board Statement not detected. Randomization not detected. Blinding not detected. Power Analysis not detected. Sex as a biological variable In particular, two GEO datasets were extracted and analyzed: 1) GSE66499, reporting microarray data on 152 normal lung samples from Caucasian individuals; 2) GSE19804, reporting microarray data on 60 normal lung samples from Taiwanese females. Table 2: Resources
Software and Algorithms Sentences Resources Gene expression data: Expression data for ACE and TMPRSS2 genes were obtained through the: 1) genotype-tissue expression (GTEx) database (https://gtexportal.org/home/), which was also used to extract quantitative trait loci (eQTLs) for the two genes … SciScore for 10.1101/2020.03.30.20047878: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
Institutional Review Board Statement not detected. Randomization not detected. Blinding not detected. Power Analysis not detected. Sex as a biological variable In particular, two GEO datasets were extracted and analyzed: 1) GSE66499, reporting microarray data on 152 normal lung samples from Caucasian individuals; 2) GSE19804, reporting microarray data on 60 normal lung samples from Taiwanese females. Table 2: Resources
Software and Algorithms Sentences Resources Gene expression data: Expression data for ACE and TMPRSS2 genes were obtained through the: 1) genotype-tissue expression (GTEx) database (https://gtexportal.org/home/), which was also used to extract quantitative trait loci (eQTLs) for the two genes (all data based on RNAseq experiments); and 2) Gene Expression Omnibus (GEO) repository (https://www.ncbi.nlm.nih.gov/geo/). Gene Expression Omnibussuggested: (Gene Expression Omnibus (GEO, RRID:SCR_005012)Genetic data: Genetic data for general European and East Asian populations were retrieved through the GnomAD repository, which contains data on a total of 125,748 exomes and 71,702 genomes (https://gnomad.broadinstitute.org/). https://gnomad.broadinstitute.org/suggested: (Genome Aggregation Database, RRID:SCR_014964)All calculations were performed using the R software (https://www.r-project.org/). https://www.r-project.org/suggested: (R Project for Statistical Computing, RRID:SCR_001905)Results from OddPub: We did not detect open data. We also did not detect open code. Researchers are encouraged to share open data when possible (see Nature blog).
Results from LimitationRecognizer: An explicit section about the limitations of the techniques employed in this study was not found. We encourage authors to address study limitations.Results from TrialIdentifier: No clinical trial numbers were referenced.
Results from Barzooka: We did not find any issues relating to the usage of bar graphs.
Results from JetFighter: We did not find any issues relating to colormaps.
Results from rtransparent:- Thank you for including a conflict of interest statement. Authors are encouraged to include this statement when submitting to a journal.
- Thank you for including a funding statement. Authors are encouraged to include this statement when submitting to a journal.
- No protocol registration statement was detected.
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