Lactate dehydrogenase, an independent risk factor of severe COVID-19 patients: a retrospective and observational study
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SciScore for 10.1101/2020.03.24.20040162: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
Institutional Review Board Statement IRB: The study was approved by the Ethics Committee of Renmin Hospital of Wuhan University. 2. Statistical Analysis: A sample size of at least 17 patients per group is needed to achieve 91% power to detect a difference of 0.3 between the area under the ROC curve (AUC) under the null hypothesis of 0.5 and an AUC under the alternative hypothesis of 0.8 using a two-sided test at a significance level of 0.05 (PASS 15, NCSS, LCC). Randomization Because the patients enrolled in our study were not randomly assigned, all statistical findings should be interpreted as descriptive only. Blinding not detected. Power Analysis The study was approved by the Ethics Committee of … SciScore for 10.1101/2020.03.24.20040162: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
Institutional Review Board Statement IRB: The study was approved by the Ethics Committee of Renmin Hospital of Wuhan University. 2. Statistical Analysis: A sample size of at least 17 patients per group is needed to achieve 91% power to detect a difference of 0.3 between the area under the ROC curve (AUC) under the null hypothesis of 0.5 and an AUC under the alternative hypothesis of 0.8 using a two-sided test at a significance level of 0.05 (PASS 15, NCSS, LCC). Randomization Because the patients enrolled in our study were not randomly assigned, all statistical findings should be interpreted as descriptive only. Blinding not detected. Power Analysis The study was approved by the Ethics Committee of Renmin Hospital of Wuhan University. 2. Statistical Analysis: A sample size of at least 17 patients per group is needed to achieve 91% power to detect a difference of 0.3 between the area under the ROC curve (AUC) under the null hypothesis of 0.5 and an AUC under the alternative hypothesis of 0.8 using a two-sided test at a significance level of 0.05 (PASS 15, NCSS, LCC). Sex as a biological variable not detected. Table 2: Resources
Software and Algorithms Sentences Resources All the analyses and figures were performed with SPSS software (Version 26) and Graphpad Prism (Version 7.0). SPSSsuggested: (SPSS, RRID:SCR_002865)Graphpad Prismsuggested: (GraphPad Prism, RRID:SCR_002798)Results from OddPub: We did not detect open data. We also did not detect open code. Researchers are encouraged to share open data when possible (see Nature blog).
Results from LimitationRecognizer: We detected the following sentences addressing limitations in the study:Our study had some limitations. This study was conducted at a single-center with limited sample size. Furthermore, because many patients remained in hospital and outcomes were unknown at the time of writing, we only collected clinical data within two weeks for our analysis. COVID-19 has spread rapidly and has a wide spectrum of severity. A larger cohort study of patients with COVID-19 pneumonia globally would help to further define the clinical characteristics and risk factors of the disease.
Results from TrialIdentifier: No clinical trial numbers were referenced.
Results from Barzooka: We did not find any issues relating to the usage of bar graphs.
Results from JetFighter: We did not find any issues relating to colormaps.
Results from rtransparent:- Thank you for including a conflict of interest statement. Authors are encouraged to include this statement when submitting to a journal.
- Thank you for including a funding statement. Authors are encouraged to include this statement when submitting to a journal.
- No protocol registration statement was detected.
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SciScore for 10.1101/2020.03.24.20040162: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
Institutional Review Board Statement The study was approved by the Ethics Committee of Renmin Hospital of Wuhan University. 2. Randomization Because the patients enrolled in our study were not randomly assigned, all statistical findings should be interpreted as descriptive only. Blinding not detected. Power Analysis Statistical Analysis A sample size of at least 17 patients per group is needed to achieve 91% power to detect a difference of 0.3 between the area under the ROC curve (AUC) under the null hypothesis of 0.5 and an AUC under the alternative hypothesis of 0.8 using a two-sided test at a significance level of 0.05 (PASS 15, NCSS, LCC). Sex as a biological variable ( 55.31 % ) were male … SciScore for 10.1101/2020.03.24.20040162: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
Institutional Review Board Statement The study was approved by the Ethics Committee of Renmin Hospital of Wuhan University. 2. Randomization Because the patients enrolled in our study were not randomly assigned, all statistical findings should be interpreted as descriptive only. Blinding not detected. Power Analysis Statistical Analysis A sample size of at least 17 patients per group is needed to achieve 91% power to detect a difference of 0.3 between the area under the ROC curve (AUC) under the null hypothesis of 0.5 and an AUC under the alternative hypothesis of 0.8 using a two-sided test at a significance level of 0.05 (PASS 15, NCSS, LCC). Sex as a biological variable ( 55.31 % ) were male of which 70.83 % were severe cases ( P < 0.05) . Table 2: Resources
Antibodies Sentences Resources In a retrospective analysis of a CTLs antigen-4 antibody which could enhance T-cell activity and proliferation , the result showed that increase in LDH level was indicative of a poor outcome(22) , that confirmed the inhibition effect of LDH on CTLs . antigen-4suggested: NoneSoftware and Algorithms Sentences Resources All the analyses and figures were performed with SPSS software (Version 26) and Graphpad Prism (Version 7.0). SPSSsuggested: (SPSS, SCR_002865)<div style="margin-bottom:8px"> <div><b>Graphpad Prism</b></div> <div>suggested: (GraphPad Prism, <a href="https://scicrunch.org/resources/Any/search?q=SCR_002798">SCR_002798</a>)</div> </div> </td></tr></table>Results from OddPub: Thank you for sharing your data.
About SciScore
SciScore is an automated tool that is designed to assist expert reviewers by finding and presenting formulaic information scattered throughout a paper in a standard, easy to digest format. SciScore is not a substitute for expert review. SciScore checks for the presence and correctness of RRIDs (research resource identifiers) in the manuscript, and detects sentences that appear to be missing RRIDs. SciScore also checks to make sure that rigor criteria are addressed by authors. It does this by detecting sentences that discuss criteria such as blinding or power analysis. SciScore does not guarantee that the rigor criteria that it detects are appropriate for the particular study. Instead it assists authors, editors, and reviewers by drawing attention to sections of the manuscript that contain or should contain various rigor criteria and key resources. For details on the results shown here, including references cited, please follow this link.
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