SARS-CoV-2 shedding, infectivity, and evolution in an immunocompromised adult patient
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SciScore for 10.1101/2021.06.11.21257717: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
Ethics not detected. Sex as a biological variable not detected. Randomization not detected. Blinding not detected. Power Analysis not detected. Cell Line Authentication not detected. Table 2: Resources
Antibodies Sentences Resources Virus Neutralization Test (VNT): The presence of anti-SARS CoV-2 antibodies was determined using a cytopathic effect (CPE)-based virus neutralization assay. anti-SARS CoV-2suggested: NoneExperimental Models: Cell Lines Sentences Resources Results of the SARS-CoV-2 isolation in Vero cells from clinical specimens are presented in Table 1. Verosuggested: CLS Cat# 605372/p622_VERO, RRID:CVCL_0059)Results from OddPub: We did not detect open data. We also did not detect open code. Researchers …
SciScore for 10.1101/2021.06.11.21257717: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
Ethics not detected. Sex as a biological variable not detected. Randomization not detected. Blinding not detected. Power Analysis not detected. Cell Line Authentication not detected. Table 2: Resources
Antibodies Sentences Resources Virus Neutralization Test (VNT): The presence of anti-SARS CoV-2 antibodies was determined using a cytopathic effect (CPE)-based virus neutralization assay. anti-SARS CoV-2suggested: NoneExperimental Models: Cell Lines Sentences Resources Results of the SARS-CoV-2 isolation in Vero cells from clinical specimens are presented in Table 1. Verosuggested: CLS Cat# 605372/p622_VERO, RRID:CVCL_0059)Results from OddPub: We did not detect open data. We also did not detect open code. Researchers are encouraged to share open data when possible (see Nature blog).
Results from LimitationRecognizer: We detected the following sentences addressing limitations in the study:A limitation of our study is that we were not able to test the contacts of the index person. Genome sequencing of viral isolates from clinical samples taken 196 days apart allowed us to observe changes in the SARS-CoV-2 genome over this prolonged time period. Studies investigating whether viral strains with the recurrent deletions associated with immune escape observed here can be effectively transmitted at the population level are urgently needed. Implementation of contact tracing, particularly for infections with longer generation intervals as described here, and continued monitorization of SARS-CoV-2 recent cases in Brazil will help to control community transmission of SARS-CoV-2 variants with altered epidemiological characteristics. In conclusion, the present study demonstrates that viable and replication competent SARS-CoV-2 virus can be recovered from pharyngeal mucosa and saliva at prolonged intervals in an immunocompromised patient. The present observations may be pertinent to the further refinement of prevention and transmission protocols.
Results from TrialIdentifier: No clinical trial numbers were referenced.
Results from Barzooka: We did not find any issues relating to the usage of bar graphs.
Results from JetFighter: We did not find any issues relating to colormaps.
Results from rtransparent:- Thank you for including a conflict of interest statement. Authors are encouraged to include this statement when submitting to a journal.
- Thank you for including a funding statement. Authors are encouraged to include this statement when submitting to a journal.
- No protocol registration statement was detected.
Results from scite Reference Check: We found no unreliable references.
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