SARS‐CoV‐2 worldwide replication drives rapid rise and selection of mutations across the viral genome: a time‐course study – potential challenge for vaccines and therapies

  1. Stefanie Weber
  2. Christina M Ramirez
  3. Barbara Weiser
  4. Harold Burger
  5. Walter Doerfler

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Abstract

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  1. Version published to 10.15252/emmm.202114062
  2. ScreenIT

    SciScore for 10.1101/2021.02.04.21251111: (What is this?)

    Please note, not all rigor criteria are appropriate for all manuscripts.

    Table 1: Rigor

    Institutional Review Board Statementnot detected.
    Randomizationnot detected.
    Blindingnot detected.
    Power Analysisnot detected.
    Sex as a biological variablenot detected.

    Table 2: Resources

    Software and Algorithms
    SentencesResources
    , Tool Align X, or Snapgene (GSL Biotech), by using the algorithm MUSCLE (Multiple Sequence Comparison by Log-Expectation), for the alignment of sequences.
    MUSCLE
    suggested: (MUSCLE, RRID:SCR_011812)
    Amino acid sequences were also analyzed with the program Snapgene.
    Snapgene
    suggested: (SnapGene, RRID:SCR_015052)

    Results from OddPub: Thank you for sharing your code.

    Results from LimitationRecognizer: An explicit section about the limitations of the techniques employed in this study was not found. We encourage authors to address study limitations.

    Results from TrialIdentifier: No clinical trial numbers were referenced.

    Results from Barzooka: We did not find any issues relating to the usage of bar graphs.

    Results from JetFighter: We did not find any issues relating to colormaps.

    Results from scite Reference Check: We found no unreliable references.

    About SciScore

    SciScore is an automated tool that is designed to assist expert reviewers by finding and presenting formulaic information scattered throughout a paper in a standard, easy to digest format. SciScore checks for the presence and correctness of RRIDs (research resource identifiers), and for rigor criteria such as sex and investigator blinding. For details on the theoretical underpinning of rigor criteria and the tools shown here, including references cited, please follow this link.

  3. Version published to 10.1101/2021.02.04.21251111v1 on medRxiv