Effect of moist heat reprocessing of N95 respirators on SARS-CoV-2 inactivation and respirator function
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SciScore for 10.1101/2020.05.25.20112615: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
Institutional Review Board Statement not detected. Randomization We analyzed fiber morphology with a blinded observer using ImageJ (https://imagej.nih.gov/ij/) in ten randomly selected individual fibers from all quadrants of a representative image of each sample. Blinding We analyzed fiber morphology with a blinded observer using ImageJ (https://imagej.nih.gov/ij/) in ten randomly selected individual fibers from all quadrants of a representative image of each sample. Power Analysis Sample size calculations for quantitative respirator fit revealed a required sample size of n=12 to detect a mean fit factor of 120 (pass value 100, mean fit factor of unprocessed mask 190±15) on an alpha level of 0.01 and a … SciScore for 10.1101/2020.05.25.20112615: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
Institutional Review Board Statement not detected. Randomization We analyzed fiber morphology with a blinded observer using ImageJ (https://imagej.nih.gov/ij/) in ten randomly selected individual fibers from all quadrants of a representative image of each sample. Blinding We analyzed fiber morphology with a blinded observer using ImageJ (https://imagej.nih.gov/ij/) in ten randomly selected individual fibers from all quadrants of a representative image of each sample. Power Analysis Sample size calculations for quantitative respirator fit revealed a required sample size of n=12 to detect a mean fit factor of 120 (pass value 100, mean fit factor of unprocessed mask 190±15) on an alpha level of 0.01 and a power of 0.95 (17). Sex as a biological variable Fitted respirators were personalized to two blinded test subjects (one male, one female) and underwent thermal disinfection at 0% RH or 50% RH respectively (n=23 each) as outlined above. Cell Line Authentication not detected. Table 2: Resources
Experimental Models: Cell Lines Sentences Resources We then titrated the recovered infectious virus particles by standard TCID50 assay using Vero E6 cells as described (5). Vero E6suggested: RRID:CVCL_XD71)Software and Algorithms Sentences Resources We analyzed fiber morphology with a blinded observer using ImageJ (https://imagej.nih.gov/ij/) in ten randomly selected individual fibers from all quadrants of a representative image of each sample. ImageJsuggested: (ImageJ, RRID:SCR_003070)Statistical methods: We conducted statistical analyses using JMP (version 15.1.0, SAS Institute, USA) SAS Institutesuggested: (Statistical Analysis System, RRID:SCR_008567)Results from OddPub: We did not detect open data. We also did not detect open code. Researchers are encouraged to share open data when possible (see Nature blog).
Results from LimitationRecognizer: An explicit section about the limitations of the techniques employed in this study was not found. We encourage authors to address study limitations.Results from TrialIdentifier: No clinical trial numbers were referenced.
Results from Barzooka: We did not find any issues relating to the usage of bar graphs.
Results from JetFighter: We did not find any issues relating to colormaps.
Results from rtransparent:- Thank you for including a conflict of interest statement. Authors are encouraged to include this statement when submitting to a journal.
- Thank you for including a funding statement. Authors are encouraged to include this statement when submitting to a journal.
- No protocol registration statement was detected.
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