Retrospective evaluation of real-time estimates of global COVID-19 transmission trends and mortality forecasts

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Abstract

Since 8 th March 2020 up to the time of writing, we have been producing near real-time weekly estimates of SARS-CoV-2 transmissibility and forecasts of deaths due to COVID-19 for all countries with evidence of sustained transmission, shared online. We also developed a novel heuristic to combine weekly estimates of transmissibility to produce forecasts over a 4-week horizon. Here we present a retrospective evaluation of the forecasts produced between 8 th March to 29 th November 2020 for 81 countries. We evaluated the robustness of the forecasts produced in real-time using relative error, coverage probability, and comparisons with null models. During the 39-week period covered by this study, both the short- and medium-term forecasts captured well the epidemic trajectory across different waves of COVID-19 infections with small relative errors over the forecast horizon. The model was well calibrated with 56.3% and 45.6% of the observations lying in the 50% Credible Interval in 1-week and 4-week ahead forecasts respectively. The retrospective evaluation of our models shows that simple transmission models calibrated using routine disease surveillance data can reliably capture the epidemic trajectory in multiple countries. The medium-term forecasts can be used in conjunction with the short-term forecasts of COVID-19 mortality as a useful planning tool as countries continue to relax public health measures.

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  1. SciScore for 10.1101/2021.07.19.21260746: (What is this?)

    Please note, not all rigor criteria are appropriate for all manuscripts.

    Table 1: Rigor

    NIH rigor criteria are not applicable to paper type.

    Table 2: Resources

    No key resources detected.


    Results from OddPub: Thank you for sharing your code and data.


    Results from LimitationRecognizer: We detected the following sentences addressing limitations in the study:
    A limitation of our work is that our estimates reflect the epidemiological situation with a delay of approximately 19 days (the delay from an infection to a death [53]). Nevertheless, our short-term forecasts and transmissibility estimates provide a valuable global overview and continuous insights into the dynamic trajectory of the epidemic in different countries. They also provide indirect evidence about the effectiveness of public health measures. Future research could investigate integrating more data streams into the models. In addition to the weekly reports that we publish, our work has also contributed to other international forecasting efforts [22, 48, 55]. We developed a simple heuristic to combine past estimates of transmissibility and a decline in the proportion of susceptible population to produce medium-term forecasts. We were able to achieve good model performance in forecasting up to 4 weeks ahead. Consistent with findings from other modelling studies [22], we found that the model error was unacceptably high beyond 4 weeks, suggesting that forecasting beyond this horizon is difficult. Importantly, our characterisation of the epidemic phase using weighted estimates of transmissibility were largely in agreement with that using short-term transmissibility estimates. Thus, our method was successful at capturing the broad trends in transmission up to 4 weeks ahead. The medium-term forecasts can therefore serve as a useful planning tool as governments around the world...

    Results from TrialIdentifier: No clinical trial numbers were referenced.


    Results from Barzooka: We did not find any issues relating to the usage of bar graphs.


    Results from JetFighter: We did not find any issues relating to colormaps.


    Results from rtransparent:
    • Thank you for including a conflict of interest statement. Authors are encouraged to include this statement when submitting to a journal.
    • Thank you for including a funding statement. Authors are encouraged to include this statement when submitting to a journal.
    • No protocol registration statement was detected.

    Results from scite Reference Check: We found no unreliable references.


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