COVID-19 is associated with higher risk of venous thrombosis, but not arterial thrombosis, compared with influenza: Insights from a large US cohort

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1. Version published to 10.1371/journal.pone.0261786

   Jan 12, 2022
2. 

   ScreenIT

   Oct 22, 2021

   SciScore for 10.1101/2021.10.15.21264137: (What is this?)

   Please note, not all rigor criteria are appropriate for all manuscripts.

   Table 1: Rigor

   Ethics	not detected.
   Sex as a biological variable	not detected.
   Randomization	not detected.
   Blinding	not detected.
   Power Analysis	not detected.

   Table 2: Resources

   Antibodies
   Sentences	Resources
   The following covariates were included in the regression model: age category, sex category, severity of infection, care setting of diagnosis, prior institutional stay, history of cardiovascular disease, venous thromboembolism, ischemic stroke, myocardial infarction, atrial fibrillation, heart failure, hyperlipidemia, hypertension, peripheral arterial disease, diabetes, neurologic disease that promotes stasis/immobility, obesity, chronic kidney disease, cancer, COPD, rheumatic disease, antiphospholipid antibody …

   SciScore for 10.1101/2021.10.15.21264137: (What is this?)

   Please note, not all rigor criteria are appropriate for all manuscripts.

   Table 1: Rigor

   Ethics	not detected.
   Sex as a biological variable	not detected.
   Randomization	not detected.
   Blinding	not detected.
   Power Analysis	not detected.

   Table 2: Resources

   Antibodies
   Sentences	Resources
   The following covariates were included in the regression model: age category, sex category, severity of infection, care setting of diagnosis, prior institutional stay, history of cardiovascular disease, venous thromboembolism, ischemic stroke, myocardial infarction, atrial fibrillation, heart failure, hyperlipidemia, hypertension, peripheral arterial disease, diabetes, neurologic disease that promotes stasis/immobility, obesity, chronic kidney disease, cancer, COPD, rheumatic disease, antiphospholipid antibody syndrome, inherited thrombophilia, polycythemia, thrombocytosis, current pregnancy, alcohol abuse, current tobacco use, and use of anticoagulants, antiplatelets, statins, oral chemotherapeutics, oral contraceptives, estrogen replacement, or testosterone replacement.	antiphospholipid suggested: None anticoagulants, suggested: None
   Software and Algorithms
   Sentences	Resources
   Analytic partners aligned on a common protocol (the current study’s methodology was adapted from the Sentinel Initiative for the FDA Natural History of Coagulopathy in COVID-19 Study Synopsis and Statistical Analysis Plan [12,13]) and conducted analyses independently; methods and results were shared side-by-side to evaluate differences and similarities.	Statistical Analysis Plan suggested: None
   Analysis was performed in Python 3.8.	Python suggested: (IPython, RRID:SCR_001658)

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   Results from OddPub: We did not detect open data. We also did not detect open code. Researchers are encouraged to share open data when possible (see Nature blog).

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   Results from LimitationRecognizer: We detected the following sentences addressing limitations in the study:

   Our study should be interpreted in the context of certain limitations. Participant-level race/ethnicity data were unavailable, preventing assessment of diverse patient representation and generalizability. Our cohort, although large, may not reflect populations across the United Status. As is inherent to observational data, unmeasured confounding may be present despite efforts to account for baseline characteristics. However, we aimed to characterize the potential impact of unmeasured confounding in an E-value analysis as shown in the Supplement. Death information was unavailable, so we were unable to directly treat death as a censoring event. However, we included the end of an individual’s claims record (i.e., the last day of a recorded claim or the last day of insurance enrollment) as a censoring event for follow-up - which should typically precede a death event - to minimize the possibility of missing a death event in an included patient. In conclusion, in a large retrospective cohort linking EHR and claims data of over 750,000 patients, we found that COVID-19 was independently associated with higher 90-day risk for venous thrombosis, but not arterial thrombosis, compared with influenza. Our work warrants expedited prospective validation to help clarify the precise nature of arterial and venous thromboembolic risks in COVID-19 and thus, the role of thromboprophylaxis in COVID-19 management.

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   Results from TrialIdentifier: No clinical trial numbers were referenced.

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   Results from Barzooka: We did not find any issues relating to the usage of bar graphs.

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   Results from JetFighter: We did not find any issues relating to colormaps.

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   Results from rtransparent:

   • Thank you for including a conflict of interest statement. Authors are encouraged to include this statement when submitting to a journal.
   • No funding statement was detected.
   • No protocol registration statement was detected.

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   Results from scite Reference Check: We found no unreliable references.

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   Read the original source
3. 

   Version published to 10.1101/2021.10.15.21264137 on medRxiv

   Oct 18, 2021