COVID-19 healthcare demand projections: Arizona

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Abstract

Beginning in March 2020, the United States emerged as the global epicenter for COVID-19 cases with little to guide policy response in the absence of extensive data available for reliable epidemiological modeling in the early phases of the pandemic. In the ensuing weeks, American jurisdictions attempted to manage disease spread on a regional basis using non-pharmaceutical interventions (i.e., social distancing), as uneven disease burden across the expansive geography of the United States exerted different implications for policy management in different regions. While Arizona policymakers relied initially on state-by-state national modeling projections from different groups outside of the state, we sought to create a state-specific model using a mathematical framework that ties disease surveillance with the future burden on Arizona’s healthcare system. Our framework uses a compartmental system dynamics model using a SEIRD framework that accounts for multiple types of disease manifestations for the COVID-19 infection, as well as the observed time delay in epidemiological findings following public policy enactments. We use a compartment initialization logic coupled with a fitting technique to construct projections for key metrics to guide public health policy, including exposures, infections, hospitalizations, and deaths under a variety of social reopening scenarios. Our approach makes use of X-factor fitting and backcasting methods to construct meaningful and reliable models with minimal available data in order to provide timely policy guidance in the early phases of a pandemic.

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  1. SciScore for 10.1101/2020.05.13.20099838: (What is this?)

    Please note, not all rigor criteria are appropriate for all manuscripts.

    Table 1: Rigor

    NIH rigor criteria are not applicable to paper type.

    Table 2: Resources

    No key resources detected.


    Results from OddPub: We did not detect open data. We also did not detect open code. Researchers are encouraged to share open data when possible (see Nature blog).


    Results from LimitationRecognizer: We detected the following sentences addressing limitations in the study:
    There are several limitations to our analysis. It is important to note that our SEIRD modeling approach did not take into account many factors that play an important role in the dynamics of disease such as heterogeneous contact transmission network, the characteristics of the population (e.g. age, comorbid health conditions, racial and ethnic disparities in access to testing and treatment), the possibility of partial immunity or no immunity from SARS-CoV-2 infection and the availability of testing and contact tracing. At the time of this report, Arizona maintained one of the lowest per capita testing and contact tracing rates of any state in the country. Therefore, it is likely that significant underdetection and thus underreporting of mild and asymptomatic cases may impact calculations of hospitalization and death rates. In order to accommodate this limitation, we used biologically plausible parameters for SARS-CoV-2 based on current evidence. As the evidence related to SARS-CoV-2 and COVID-19 continues to develop, these values are likely to be updated as more comprehensive data become available. In future work, we look forward to testing this model more broadly against data from other states beyond Arizona in an effort to validate this approach for other public health policy making jurisdictions. In addition, we plan to test this modeling approach more narrowly by applying it to county-specific data in Arizona in order to assess the retrospective accuracy given a more homog...

    Results from TrialIdentifier: No clinical trial numbers were referenced.


    Results from Barzooka: We did not find any issues relating to the usage of bar graphs.


    Results from JetFighter: We did not find any issues relating to colormaps.


    Results from rtransparent:
    • Thank you for including a conflict of interest statement. Authors are encouraged to include this statement when submitting to a journal.
    • Thank you for including a funding statement. Authors are encouraged to include this statement when submitting to a journal.
    • No protocol registration statement was detected.

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