Effect of blood analysis and immune function on the prognosis of patients with COVID-19

  1. Yue-Qiang Fu
  2. Yue-Lin Sun
  3. Si-Wei Lu
  4. Yang Yang
  5. Yi Wang
  6. Feng Xu

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Abstract

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  1. Version published to 10.1371/journal.pone.0240751
  2. ScreenIT

    SciScore for 10.1101/2020.04.16.20067587: (What is this?)

    Please note, not all rigor criteria are appropriate for all manuscripts.

    Table 1: Rigor

    Institutional Review Board StatementIRB: Study design: The Ethics Committee of Children’s Hospital, Chongqing Medical University (Institutional Review Board of Children’s Hospital, Chongqing Medical University) approved this retrospective cohort study.
    Consent: The requirement for written informed consent was waived because of the retrospective design.
    Randomizationnot detected.
    Blindingnot detected.
    Power Analysisnot detected.
    Sex as a biological variablenot detected.

    Table 2: Resources

    Software and Algorithms
    SentencesResources
    Statistical analysis: Data were analyzed using SPSS 21.0 (SPSS, Chicago, IL, USA).
    SPSS
    suggested: (SPSS, RRID:SCR_002865)

    Results from OddPub: We did not detect open data. We also did not detect open code. Researchers are encouraged to share open data when possible (see Nature blog).

    Results from LimitationRecognizer: We detected the following sentences addressing limitations in the study:
    For the present patients with COVID-19, we found that neutrophil count was above the higher limitation of normal range in 12(85.71%) dead patients and an initial elevated neutrophil count was an independent risk factor of mortality. This significant elevation of neutrophil count in the death group, may reflect a strong inflammatory response toward viral infection, or a possible combination with bacterial infection. The specific mechanism needs further study. The report of Wang et al. [9] on patients with COVID-19 showed that the lymphocyte count continued to decrease with progression, unto death. The latest researches showed that the severe COVID-19 cases had significantly lower lymphocyte counts compared with non-severe COVID-19 cases [8-13]. The present study also determined that more than half of the patients (53/85, 62.35%) had lower lymphocyte count than the lower limitation of normal, especially in those who died (12/14, 85.7%). And we found that the lymphocyte counts in dead group were significantly lower than those in survival group. It is not clear whether there are other mechanisms for lymphocyte decline in COVID-19, other than the destruction of lymphoid organs by viral attack. Lymphopenia in patients with SARS before hormone therapy may be induced by a stress mechanism involving the hypothalamus-pituitary-adrenal axis, due to elevation of the cortisol level [17]. Lymphocyte subsets have an important role in humoral and cellular immunity against viral infection. Th...

    Results from TrialIdentifier: No clinical trial numbers were referenced.

    Results from Barzooka: We did not find any issues relating to the usage of bar graphs.

    Results from JetFighter: We did not find any issues relating to colormaps.

    Results from rtransparent:
    • Thank you for including a conflict of interest statement. Authors are encouraged to include this statement when submitting to a journal.
    • Thank you for including a funding statement. Authors are encouraged to include this statement when submitting to a journal.
    • No protocol registration statement was detected.

    About SciScore

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  3. Version published to 10.1101/2020.04.16.20067587 on medRxiv