Clinical laboratory parameters associated with severe or critical novel coronavirus disease 2019 (COVID-19): A systematic review and meta-analysis
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Abstract
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SciScore for 10.1101/2020.04.24.20078782: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
Institutional Review Board Statement not detected. Randomization not detected. Blinding not detected. Power Analysis not detected. Sex as a biological variable Also, as children and pregnant women have different cut-off values for most clinical laboratory parameters compared to general adults, we excluded studies that examined populations with large proportions of children under 11 years of age and pregnant women to reduce clinical heterogeneity. Table 2: Resources
Software and Algorithms Sentences Resources , EBSCO CINAHL and Google Scholar databases from 2019 through April 18, 2020. Google Scholarsuggested: (Google Scholar, RRID:SCR_008878)Results from OddPub: We did not detect open data. We also did not …
SciScore for 10.1101/2020.04.24.20078782: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
Institutional Review Board Statement not detected. Randomization not detected. Blinding not detected. Power Analysis not detected. Sex as a biological variable Also, as children and pregnant women have different cut-off values for most clinical laboratory parameters compared to general adults, we excluded studies that examined populations with large proportions of children under 11 years of age and pregnant women to reduce clinical heterogeneity. Table 2: Resources
Software and Algorithms Sentences Resources , EBSCO CINAHL and Google Scholar databases from 2019 through April 18, 2020. Google Scholarsuggested: (Google Scholar, RRID:SCR_008878)Results from OddPub: We did not detect open data. We also did not detect open code. Researchers are encouraged to share open data when possible (see Nature blog).
Results from LimitationRecognizer: We detected the following sentences addressing limitations in the study:The strengths and limitations of this review and meta-analysis need to be considered in the context of rapidly evolving literature. On the one hand, our study identified some associations that deserve further consideration and may lead to improvements in the risk stratification, monitoring and management of COVID-19 patients. On the other hand, it is important to emphasize that our analyses need to be viewed as hypothesis-generating rather than hypothesis-testing. Due to the large number of associations examined simultaneously there is a considerable likelihood of false-positive findings. This limitation can be addressed in future, more focused, studies that will take into consideration prior knowledge and reduce the likelihood of false-positive results through application of Bayesian and empirical-Bayes methods [43]. Our review is also affected by the limitations of the underlying literature. Of those, perhaps the most important is the cross-sectional nature of the analyses used in most publications. Although it is plausible that markers of immune function can be used to predict disease severity, the evidence would have been stronger if the studies were able to perform laboratory testing of COVID-19 patients before their disease severity was known. In addition, many studies from China reported on overlapping patient populations. While we tried to exclude studies that relied on the same data, it is possible that some of the associations examined in this meta-analysis were bas...
Results from TrialIdentifier: No clinical trial numbers were referenced.
Results from Barzooka: We did not find any issues relating to the usage of bar graphs.
Results from JetFighter: We did not find any issues relating to colormaps.
Results from rtransparent:- Thank you for including a conflict of interest statement. Authors are encouraged to include this statement when submitting to a journal.
- Thank you for including a funding statement. Authors are encouraged to include this statement when submitting to a journal.
- No protocol registration statement was detected.
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