Health inequities in SARS-CoV-2 infection, seroprevalence, and COVID-19 vaccination: Results from the East Bay COVID-19 study

Article activity feed

1. Version published to 10.1371/journal.pgph.0000647

   Aug 15, 2022
2. 

   ScreenIT

   Dec 8, 2021

   SciScore for 10.1101/2021.12.02.21266871: (What is this?)

   Please note, not all rigor criteria are appropriate for all manuscripts.

   Table 1: Rigor

   Ethics	Consent: In the screening phase, all residential addresses within the East Bay cities and communities of Albany, Berkeley, El Cerrito, El Sobrante, Emeryville, Hercules, Kensington, Oakland, Piedmont, Pinole, Richmond, and San Pablo (∼307,000 residential households) were mailed an invitation to complete a consent form and screening questionnaire.
   Sex as a biological variable	not detected.
   Randomization	Order of inclusion for Whites was randomly sampled.
   Blinding	not detected.
   Power Analysis	not detected.

   Table 2: Resources

   Antibodies
   Sentences	Resources
   Three tests were used to assess anti-SARS-CoV-2 antibodies in DBS: Ortho VITROS® Anti-SARS-CoV-2 Total IgG and spike IgG ELISA targeted antibodies …

   SciScore for 10.1101/2021.12.02.21266871: (What is this?)

   Please note, not all rigor criteria are appropriate for all manuscripts.

   Table 1: Rigor

   Ethics	Consent: In the screening phase, all residential addresses within the East Bay cities and communities of Albany, Berkeley, El Cerrito, El Sobrante, Emeryville, Hercules, Kensington, Oakland, Piedmont, Pinole, Richmond, and San Pablo (∼307,000 residential households) were mailed an invitation to complete a consent form and screening questionnaire.
   Sex as a biological variable	not detected.
   Randomization	Order of inclusion for Whites was randomly sampled.
   Blinding	not detected.
   Power Analysis	not detected.

   Table 2: Resources

   Antibodies
   Sentences	Resources
   Three tests were used to assess anti-SARS-CoV-2 antibodies in DBS: Ortho VITROS® Anti-SARS-CoV-2 Total IgG and spike IgG ELISA targeted antibodies against the SARS-CoV-2 spike protein (indicating prior natural infection or vaccination), and Roche-NC Total IgG targeted antibodies against the nucleocapsid (NC) protein (indicating prior natural infection only).(13) Before COVID-19 vaccines were available in the study region during rounds 1 and 2, detection of antibodies against the SARS-CoV-2 spike protein was considered evidence of SARS-CoV-2 infection.	anti-SARS-CoV-2 suggested: None Anti-SARS-CoV-2 Total IgG suggested: None Roche-NC Total IgG suggested: None
   DBS samples that tested both negative for anti-NC antibodies and positive for anti-spike antibodies in Round 3 were considered to have antibodies from COVID-19 vaccination alone.	anti-NC suggested: None anti-spike suggested: (GeneTex Cat# GTX632604, RRID:AB_2864418)

   ---

   Results from OddPub: Thank you for sharing your code.

   ---

   Results from LimitationRecognizer: We detected the following sentences addressing limitations in the study:

   One limitation of this study was the under-representation of certain demographics in our sample. Supplementary mailings of recruitment postcards in Spanish were sent to residences in ZIP codes with high proportions of Spanish speaking households. We also placed recruitment flyers in local grocery stores and conducted outreach to community organizations, local government officials, and school districts in the study region. Despite these efforts, non-Whites, males, lower income households, and individuals with lower education and from lower socioeconomic ZIP codes were underrepresented in our sample. Unhoused individuals were also not captured in our sample. This was important given evidence that individuals who identify as Hispanic or Black, and other underrepresented groups, are at the highest risk for COVID-19.(23) These discrepancies may have led to underestimation of overall SARS-CoV-2 seroprevalence and self-reported infection, although the MRP models may have somewhat minimized this effect by pooling information across similar observed characteristics in the sample data. Our seroprevalence estimates were consistent with weekly case prevalence reported by public health agencies in ZIP codes with high response rates (Figure S-5).(29) Additionally, there may be unmeasured confounding from variables not included in the analyses and self-selection bias from some participants in COVID-19 research who may be more fervent adherers to COVID-19 public health measures. Finally, som...

   ---

   Results from TrialIdentifier: No clinical trial numbers were referenced.

   ---

   Results from Barzooka: We did not find any issues relating to the usage of bar graphs.

   ---

   Results from JetFighter: We did not find any issues relating to colormaps.

   ---

   Results from rtransparent:

   • Thank you for including a conflict of interest statement. Authors are encouraged to include this statement when submitting to a journal.
   • Thank you for including a funding statement. Authors are encouraged to include this statement when submitting to a journal.
   • No protocol registration statement was detected.

   ---

   Results from scite Reference Check: We found no unreliable references.

   ---

   Read the original source
3. 

   Version published to 10.1101/2021.12.02.21266871 on medRxiv

   Dec 5, 2021