Recent Covid-19 Vaccination Is Associated With Modest Increases In The Physiological Demands To Graded Exercise
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SciScore for 10.1101/2021.08.24.21262239: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
Ethics Consent: All participants provided written informed consent prior to participating in the study and the Institutional Review Board (IRB) of the University of Arizona granted ethical approval.
IRB: All participants provided written informed consent prior to participating in the study and the Institutional Review Board (IRB) of the University of Arizona granted ethical approval.Sex as a biological variable Participants: A total of eighteen (9 females, 9 males) healthy individuals between the ages of 24-43 years participated in this study. Randomization not detected. Blinding not detected. Power Analysis not detected. Table 2: Resources
Software and Algorithms Sentences Resources All statistical analyses … SciScore for 10.1101/2021.08.24.21262239: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
Ethics Consent: All participants provided written informed consent prior to participating in the study and the Institutional Review Board (IRB) of the University of Arizona granted ethical approval.
IRB: All participants provided written informed consent prior to participating in the study and the Institutional Review Board (IRB) of the University of Arizona granted ethical approval.Sex as a biological variable Participants: A total of eighteen (9 females, 9 males) healthy individuals between the ages of 24-43 years participated in this study. Randomization not detected. Blinding not detected. Power Analysis not detected. Table 2: Resources
Software and Algorithms Sentences Resources All statistical analyses were completed using GraphPad Prism 8.0. GraphPad Prismsuggested: (GraphPad Prism, RRID:SCR_002798)Results from OddPub: We did not detect open data. We also did not detect open code. Researchers are encouraged to share open data when possible (see Nature blog).
Results from LimitationRecognizer: We detected the following sentences addressing limitations in the study:While providing the first report of physiological responses to graded exercise following COVID-19 vaccination, we acknowledge several study limitations. The small sample size may not only have prevented us from finding additional effects of vaccination on the exercise response, but also limited our ability to compare the response among infected and non-infected individuals who had received different types of COVID-19 vaccine. Further, we did not include an endpoint measure of exercise performance (e.g., cycling time trial or peak power test) and did not perform follow up assessments to determine the time course for these physiological responses to exercise to return to pre-vaccination levels. We purposefully tested our participants 2-3 weeks after vaccination as this is within the timeframe for neutralizing antibody production and SARS-CoV-2 T-cell detection (16), and because athletes are oftentimes vaccinated in close proximity to competition (7). As we did not administer the vaccines ourselves, we also had no control over the timing of the vaccine or the type of vaccine each individual received. Despite these acknowledged limitations, we conclude that recent COVID-19 vaccination is associated with modest increases in the physiological demands to graded exercise, particularly in those receiving two doses of an mRNA vaccine and with no history of SARS-CoV-2 infection. These findings could have practical implications for athletes in regards to when COVID-19 vaccines are admini...
Results from TrialIdentifier: We found the following clinical trial numbers in your paper:
Identifier Status Title NCT05019456 Recruiting Exercise and Total Viral Immunity Results from Barzooka: We did not find any issues relating to the usage of bar graphs.
Results from JetFighter: We did not find any issues relating to colormaps.
Results from rtransparent:- Thank you for including a conflict of interest statement. Authors are encouraged to include this statement when submitting to a journal.
- Thank you for including a funding statement. Authors are encouraged to include this statement when submitting to a journal.
- No protocol registration statement was detected.
Results from scite Reference Check: We found no unreliable references.
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