Frequency of Neurologic Manifestations in COVID-19
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Abstract
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SciScore for 10.1101/2021.04.20.21255780: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
Ethics not detected. Sex as a biological variable not detected. Randomization not detected. Blinding not detected. Power Analysis not detected. Table 2: Resources
Antibodies Sentences Resources Population: The target population for this review includes patients clinically suspected to have COVID-19 confirmed by real-time reverse-transcription polymerase chain reaction (RT-PCR) detection, high throughput sequencing, SARS-CoV-2 viral culture in throat swab specimens, or SARS-CoV-2 antibody detection in blood samples. SARS-CoV-2suggested: NoneSoftware and Algorithms Sentences Resources A comprehensive literature search was carried out for the period 31st December 2019 to 15th December 2020 in PubMed, EMBASE, … SciScore for 10.1101/2021.04.20.21255780: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
Ethics not detected. Sex as a biological variable not detected. Randomization not detected. Blinding not detected. Power Analysis not detected. Table 2: Resources
Antibodies Sentences Resources Population: The target population for this review includes patients clinically suspected to have COVID-19 confirmed by real-time reverse-transcription polymerase chain reaction (RT-PCR) detection, high throughput sequencing, SARS-CoV-2 viral culture in throat swab specimens, or SARS-CoV-2 antibody detection in blood samples. SARS-CoV-2suggested: NoneSoftware and Algorithms Sentences Resources A comprehensive literature search was carried out for the period 31st December 2019 to 15th December 2020 in PubMed, EMBASE, MEDLINE, Google Scholar, Cochrane Library and ClinicalTrials.gov. PubMedsuggested: (PubMed, RRID:SCR_004846)EMBASEsuggested: (EMBASE, RRID:SCR_001650)MEDLINEsuggested: (MEDLINE, RRID:SCR_002185)Google Scholarsuggested: (Google Scholar, RRID:SCR_008878)Cochrane Librarysuggested: (Cochrane Library, RRID:SCR_013000)Results from OddPub: We did not detect open data. We also did not detect open code. Researchers are encouraged to share open data when possible (see Nature blog).
Results from LimitationRecognizer: We detected the following sentences addressing limitations in the study:Limitations of this review: There are several important limitations for this review. Firstly, there are few data from prospective studies; most data came from retrospective cohorts or case series. Additionally, standardized classifications, definitions, and diagnostic criteria of neurological manifestations were not uniformly used or reported. Moreover, studies relating to many manifestations were not suitable for pooling. Thirdly, as the vast majority of data analyzed came from hospitalized cases (89%), our pooled prevalence estimates of neurological manifestations, especially those of severe manifestations such as stroke, may not represent community prevalence. We are therefore unable to draw conclusions regarding the prevalence of neurological manifestations amongst COVID-19 patients in the community. Additionally, interpretation of data regarding pre-existing neurological conditions and COVID-19 diagnoses is limited due to the proportion of hospitalized cases studied. Meta-analyses for most outcomes in this review had a high degree of heterogeneity, which could only partly be explained by meta-regression and subgroup analyses. It is expected that the patient populations in the included studies were clinically diverse, having presented to centers with varied referral pathways, and this may have contributed to the heterogeneity observed. For almost all symptoms, studies with higher risk of bias yielded higher pooled prevalence, indicating overestimation from bias in selecti...
Results from TrialIdentifier: No clinical trial numbers were referenced.
Results from Barzooka: We did not find any issues relating to the usage of bar graphs.
Results from JetFighter: We did not find any issues relating to colormaps.
Results from rtransparent:- Thank you for including a conflict of interest statement. Authors are encouraged to include this statement when submitting to a journal.
- Thank you for including a funding statement. Authors are encouraged to include this statement when submitting to a journal.
- No protocol registration statement was detected.
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