Plasma Markers of Neurologic Injury and Inflammation in People With Self-Reported Neurologic Postacute Sequelae of SARS-CoV-2 Infection
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SciScore for 10.1101/2021.11.02.21265778: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
Ethics Consent: Ethics: All participants provided written informed consent.
IRB: The study was approved by the Institutional Review Board at the University of California, San Francisco.Sex as a biological variable not detected. Randomization not detected. Blinding Those performing the assays were blinded to clinical information. Power Analysis not detected. Table 2: Resources
Software and Algorithms Sentences Resources Biomarker assays: Plasma biomarker measurements were performed using the fully automated HD-X Simoa platform at two timepoints: early recovery (median 52 days) and late recovery (median 123 days). Plasmasuggested: NoneWe used Stata (version 16.1; StataCorp, College Station, TX) and Prism … SciScore for 10.1101/2021.11.02.21265778: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
Ethics Consent: Ethics: All participants provided written informed consent.
IRB: The study was approved by the Institutional Review Board at the University of California, San Francisco.Sex as a biological variable not detected. Randomization not detected. Blinding Those performing the assays were blinded to clinical information. Power Analysis not detected. Table 2: Resources
Software and Algorithms Sentences Resources Biomarker assays: Plasma biomarker measurements were performed using the fully automated HD-X Simoa platform at two timepoints: early recovery (median 52 days) and late recovery (median 123 days). Plasmasuggested: NoneWe used Stata (version 16.1; StataCorp, College Station, TX) and Prism (version 9.1.2, GraphPad Software, L.L.C., San Diego, CA). StataCorpsuggested: (Stata, RRID:SCR_012763)Prismsuggested: (PRISM, RRID:SCR_005375)GraphPadsuggested: (GraphPad Prism, RRID:SCR_002798)Results from OddPub: We did not detect open data. We also did not detect open code. Researchers are encouraged to share open data when possible (see Nature blog).
Results from LimitationRecognizer: We detected the following sentences addressing limitations in the study:Our analysis has several important limitations. First, while recruitment was agnostic to the presence of persistent symptoms, the cohort is not representative of the general population with PASC. Second, we relied on self-report to ascertain the presence of symptoms. This risks misattribution of symptoms to neurologic causes and therefore misclassification of individuals as having CNS PASC. In addition, it is difficult to disentangle neurologic symptoms from non-neurologic symptoms which might co-occur and it is possible that differences are driven by more severe PASC in general rather than neurologic symptoms specifically. Affective symptoms may also co-occur and be inter-related. Third, we did not include any objective neurologic measurements, and studies that do include such measurements (which may include detailed neurological history and examination, neurocognitive and neuropsychiatric testing, and/or neuroimaging) are likely to be more informative. Fourth, we measured a limited set of biomarkers. Our measurements were all taken in blood, and while there are established relationships between blood and CSF measurements in other disease conditions,62,63 these have yet to be established for COVID-19.28 For this reason, more detailed studies that include CSF analyses will be critical. Finally, paired pre-pandemic specimens were not available, and it is possible that elevations in these markers among those with CNS PASC preceded SARS-CoV-2 infection. Regardless, we believe th...
Results from TrialIdentifier: We found the following clinical trial numbers in your paper:
Identifier Status Title NCT04362150 Recruiting Long-term Impact of Infection With Novel Coronavirus (COVID-… Results from Barzooka: We did not find any issues relating to the usage of bar graphs.
Results from JetFighter: We did not find any issues relating to colormaps.
Results from rtransparent:- Thank you for including a conflict of interest statement. Authors are encouraged to include this statement when submitting to a journal.
- Thank you for including a funding statement. Authors are encouraged to include this statement when submitting to a journal.
- No protocol registration statement was detected.
Results from scite Reference Check: We found no unreliable references.
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