Interplay between the genetics of personality traits, severe psychiatric disorders and COVID-19 host genetics in the susceptibility to SARS-CoV-2 infection

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1. Version published to 10.1192/bjo.2021.1030

   Oct 7, 2021
2. 

   ScreenIT

   Sep 16, 2021

   SciScore for 10.1101/2021.09.12.21263447: (What is this?)

   Please note, not all rigor criteria are appropriate for all manuscripts.

   Table 1: Rigor

   Ethics	IRB: The authors assert that all procedures contributing to this work comply with the ethical standards of the relevant national and institutional committees on human experimentation and with the Helsinki Declaration of 1975, as revised in 2008. Consent: Written informed consent was obtained from all study subjects.
   Sex as a biological variable	All genotyped participants of the PsyCourse Study with a diagnosis from the psychotic-to-affective spectrum as well as controls (n=1346, age [mean±SD] 47.75±13.81, 47.39% female) or for whom an extraversion score was available (n= 1190) were included in the analysis.
   Randomization	not detected.
   Blinding	not detected.
   Power Analysis	not detected.

   Table 2: …

   SciScore for 10.1101/2021.09.12.21263447: (What is this?)

   Please note, not all rigor criteria are appropriate for all manuscripts.

   Table 1: Rigor

   Ethics	IRB: The authors assert that all procedures contributing to this work comply with the ethical standards of the relevant national and institutional committees on human experimentation and with the Helsinki Declaration of 1975, as revised in 2008. Consent: Written informed consent was obtained from all study subjects.
   Sex as a biological variable	All genotyped participants of the PsyCourse Study with a diagnosis from the psychotic-to-affective spectrum as well as controls (n=1346, age [mean±SD] 47.75±13.81, 47.39% female) or for whom an extraversion score was available (n= 1190) were included in the analysis.
   Randomization	not detected.
   Blinding	not detected.
   Power Analysis	not detected.

   Table 2: Resources

   Software and Algorithms
   Sentences	Resources
   DNA samples of PsyCourse participants were genotyped on the Illumina Infinium PsychArray, and imputed using the 1000 Genomes project dataset as reference panel (for details, see(23)).	1000 Genomes suggested: (1000 Genomes Project and AWS, RRID:SCR_008801)
   PRS scoring and association testing using linear or ordinal regressions were implemented in PLINK (version 1.9) and R (version 4.0.3).	PLINK suggested: (PLINK, RRID:SCR_001757)

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   Results from OddPub: We did not detect open data. We also did not detect open code. Researchers are encouraged to share open data when possible (see Nature blog).

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   Results from LimitationRecognizer: We detected the following sentences addressing limitations in the study:

   An additional limitation lies in the fact that no direct risk assessment was possible for the individuals with individual-level data on major psychiatric disorders and personality traits since no COVID-19 phenotypes were available. Lastly, we are unable to fully exclude sample overlap especially on the side of the controls used in the included GWAS. However, LDSC results should be robust to both of these overlaps(18). Hypothetically, it is possible that—for example—only a small subset of common genetic risk factors in a given pathway relevant to major psychiatric disorders or personality traits is associated with COVID-19 susceptibility. Although we cannot fully exclude all such effects, our data suggest that non-genetic factors play important roles in the interplay between personality traits and COVID-19. A direct genetic overlap is unlikely to contribute to the increased, but yet-unexplained COVID-19 risk seen in individuals with a psychiatric diagnosis prior to SARS-CoV-2 infection(4) but a shared genetic risk could still be mediated by intermediate phenotypes such as, for example, lower socio-economic status or educational attainment in those with severe psychotic disorders. As a consequence, an even greater focus should be placed on psychosocial interventions, ensuring the best treatment for individuals with severe psychiatric disorders as well as targeted measures of prevention and psychoeducation for individuals with personality determinants that place them at an incre...

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   Results from TrialIdentifier: No clinical trial numbers were referenced.

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   Results from Barzooka: We did not find any issues relating to the usage of bar graphs.

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   Results from JetFighter: We did not find any issues relating to colormaps.

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   Results from rtransparent:

   • Thank you for including a conflict of interest statement. Authors are encouraged to include this statement when submitting to a journal.
   • Thank you for including a funding statement. Authors are encouraged to include this statement when submitting to a journal.
   • No protocol registration statement was detected.

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   Results from scite Reference Check: We found no unreliable references.

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3. 

   Version published to 10.1101/2021.09.12.21263447v1 on medRxiv

   Sep 14, 2021