Distinct temporal characteristics of circulating alveolar epithelial and endothelial injury markers in ARDS with COVID-19

  1. Kentaro Tojo
  2. Natsuhiro Yamamoto
  3. Takahiro Mihara
  4. Miyo Abe
  5. Takahisa Goto

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Abstract

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  1. Version published to 10.1186/s13054-021-03596-4
  2. Version published to 10.1101/2021.01.10.21249528v3 on medRxiv
  3. Version published to 10.1101/2021.01.10.21249528v2 on medRxiv
  4. ScreenIT

    SciScore for 10.1101/2021.01.10.21249528: (What is this?)

    Please note, not all rigor criteria are appropriate for all manuscripts.

    Table 1: Rigor

    Institutional Review Board StatementIRB: The study protocol was reviewed and approved by the institutional review board of Yokohama City University Hospital (B200700100).
    Consent: Informed consent was waived in view of the retrospective observational nature of the study.
    Randomizationnot detected.
    Blindingnot detected.
    Power Analysisnot detected.
    Sex as a biological variablenot detected.

    Table 2: Resources

    No key resources detected.

    Results from OddPub: We did not detect open data. We also did not detect open code. Researchers are encouraged to share open data when possible (see Nature blog).

    Results from LimitationRecognizer: We detected the following sentences addressing limitations in the study:
    There are some limitations to our study. First, the sample size was small because of the factor of availability of daily serum samples from patients with COVID-19 ARDS. This may have affected the statistical strength of our analyses. It is, hence, necessary to confirm our results using samples from large cohorts to obtain insights into the pathogenesis of alveolar tissue injury during COVID-19. Second, because of the observational nature of the study design, treatments for COVID-19 were not standardized. Therefore, it is possible that the treatment strategies might affect the kinetics of circulating alveolar tissue injury markers. In conclusion, our evaluation of circulating alveolar tissue injury markers indicates that the alveolar epithelial and endothelial injury have distinct time courses and pathogenic contributions in ARDS with COVID-19. The injury to endothelial cells, which continues for a longer period than the epithelial injury, seems to be the main contributor to alveolar barrier disruption. Targeting the endothelial injury rather than the epithelial injury, may be a potential efficacious approach to overcome ARDS with COVID-19.

    Results from TrialIdentifier: No clinical trial numbers were referenced.

    Results from Barzooka: We did not find any issues relating to the usage of bar graphs.

    Results from JetFighter: We did not find any issues relating to colormaps.

    Results from rtransparent:
    • Thank you for including a conflict of interest statement. Authors are encouraged to include this statement when submitting to a journal.
    • Thank you for including a funding statement. Authors are encouraged to include this statement when submitting to a journal.
    • No protocol registration statement was detected.

    About SciScore

    SciScore is an automated tool that is designed to assist expert reviewers by finding and presenting formulaic information scattered throughout a paper in a standard, easy to digest format. SciScore checks for the presence and correctness of RRIDs (research resource identifiers), and for rigor criteria such as sex and investigator blinding. For details on the theoretical underpinning of rigor criteria and the tools shown here, including references cited, please follow this link.

  5. Version published to 10.1101/2021.01.10.21249528v1 on medRxiv