Adjuvant corticosteroid therapy for critically ill patients with COVID-19
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Abstract
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SciScore for 10.1101/2020.04.07.20056390: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
Institutional Review Board Statement Consent: The Ethics Commission of Tongji hospital approved this study, with a waiver of informed consent. Randomization not detected. Blinding not detected. Power Analysis not detected. Sex as a biological variable not detected. Table 2: Resources
No key resources detected.
Results from OddPub: We did not detect open data. We also did not detect open code. Researchers are encouraged to share open data when possible (see Nature blog).
Results from LimitationRecognizer: We detected the following sentences addressing limitations in the study:We acknowledged limitations of the study. First, we did not distinguish patients who received corticosteroids for their underlying …
SciScore for 10.1101/2020.04.07.20056390: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
Institutional Review Board Statement Consent: The Ethics Commission of Tongji hospital approved this study, with a waiver of informed consent. Randomization not detected. Blinding not detected. Power Analysis not detected. Sex as a biological variable not detected. Table 2: Resources
No key resources detected.
Results from OddPub: We did not detect open data. We also did not detect open code. Researchers are encouraged to share open data when possible (see Nature blog).
Results from LimitationRecognizer: We detected the following sentences addressing limitations in the study:We acknowledged limitations of the study. First, we did not distinguish patients who received corticosteroids for their underlying disease (e.g., COPD), the number of which was however relatively small. Second, PSM is limited by adjusting for observed covariables only, but in randomized trials randomization balances for known and unknown factors. Owing to this limitation, randomized placebo-controlled trials are warranted to resolve this clinically essential issue. Altogether, abuse of corticosteroids is highly opposed and this study provided evidence that low-dose corticosteroids within effective limits may be recommended for critically ill patients with COVID-19 under certain circumstances.
Results from TrialIdentifier: No clinical trial numbers were referenced.
Results from Barzooka: We did not find any issues relating to the usage of bar graphs.
Results from JetFighter: We did not find any issues relating to colormaps.
Results from rtransparent:- Thank you for including a conflict of interest statement. Authors are encouraged to include this statement when submitting to a journal.
- Thank you for including a funding statement. Authors are encouraged to include this statement when submitting to a journal.
- No protocol registration statement was detected.
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