Inhibition of PRMT5 triggers synthetic lethality in ARID1A-deficient endometrial cancer by promoting aberrant R-loop accumulation

  1. Wan Shu
  2. Kejun Dong
  3. Xiaoyu Shen
  4. Xing Zhou
  5. Jiarui Zhang
  6. Shuyang Yu
  7. Shuangshuang Cheng
  8. Tangansu Zhang
  9. Guanxiao Chen
  10. Guanglei Zhong
  11. Jun Zhang
  12. Hongbo Wang
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  1. Version published to 10.1186/s12943-026-02629-2
  2. Version published to 10.21203/rs.3.rs-7702632/v1 on Research Square