Limited recovery from post-acute sequelae of SARS-CoV-2 at 8 months in a prospective cohort

  1. David Ross Darley
  2. Gregory John Dore
  3. Anthony Luke Byrne
  4. Marshall Lawrence Plit
  5. Bruce James Brew
  6. Anthony Kelleher
  7. Gail Veronica Matthews

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Abstract

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  1. Version published to 10.1183/23120541.00384-2021
  2. ScreenIT

    SciScore for 10.1101/2021.03.29.21254211: (What is this?)

    Please note, not all rigor criteria are appropriate for all manuscripts.

    Table 1: Rigor

    Institutional Review Board Statementnot detected.
    Randomizationnot detected.
    Blindingnot detected.
    Power Analysisnot detected.
    Sex as a biological variablenot detected.

    Table 2: Resources

    Software and Algorithms
    SentencesResources
    The ADAPT study is a prospective cohort at St Vincent’s Hospital Sydney, with nasopharyngeal swab-confirmed SARS-CoV-2 infection, being followed for up to 24 months (4).
    ADAPT
    suggested: (ADAPT, RRID:SCR_006769)
    Statistical analyses were performed using Prism Version 8.4.3.
    Prism
    suggested: (PRISM, RRID:SCR_005375)

    Results from OddPub: We did not detect open data. We also did not detect open code. Researchers are encouraged to share open data when possible (see Nature blog).

    Results from LimitationRecognizer: We detected the following sentences addressing limitations in the study:
    Our study has several limitations. Our definition for Long COVID is conservative and based on the presence of one or more of three major symptoms of fatigue, shortness of breath or chest tightness. It does not include the full spectrum of symptoms after initial infection and is thus a probable underestimate of the true burden of ill health in this population. A third of patients were referred into the study, the reasons for which varied. In many cases this was due to concern over ongoing symptoms. To address this potential selection bias, we excluded the externally referred patients from the description of symptom prevalence and included them only for outcome analysis where we had longitudinal follow-up to compare within-individual change. In summary, a considerable proportion of patients experience persistent symptoms after SARS-CoV-2 infection and a fifth of patient met our definition for Long COVID at 8 months. Persistent symptoms impact HRQoL and there appears to be little change between 4- and 8-months. A significant proportion of patients experience abnormal functional recovery at 8-months. The long-term significance of these findings is unknown.

    Results from TrialIdentifier: No clinical trial numbers were referenced.

    Results from Barzooka: We did not find any issues relating to the usage of bar graphs.

    Results from JetFighter: We did not find any issues relating to colormaps.

    Results from rtransparent:
    • Thank you for including a conflict of interest statement. Authors are encouraged to include this statement when submitting to a journal.
    • Thank you for including a funding statement. Authors are encouraged to include this statement when submitting to a journal.
    • No protocol registration statement was detected.

    About SciScore

    SciScore is an automated tool that is designed to assist expert reviewers by finding and presenting formulaic information scattered throughout a paper in a standard, easy to digest format. SciScore checks for the presence and correctness of RRIDs (research resource identifiers), and for rigor criteria such as sex and investigator blinding. For details on the theoretical underpinning of rigor criteria and the tools shown here, including references cited, please follow this link.

  3. Version published to 10.1101/2021.03.29.21254211v1 on medRxiv